백반증에서 미세분할 레이저의 색소침착 유도 효과: 예보 (Pigment Induction with a Fractional Laser for Vitiligo: A Preliminary Study)

서지정보

· 발행기관 : 대한피부과학회
· 수록지 정보 : 대한피부과학회지 / 47권 / 5호 / 547 ~ 553페이지
· 저자명 : 정승현, 정윤, 황규광

초록

Background: Numerous modalities of treatment for vitiligo have been introduced and have been proposed; however,
treatment for vitiligo remains challenging with no adequate solution.
Objective: This study was designed to examine the capability of the use of a fractional laser to induce pigmentation
for vitiligo and to investigate the therapeutic and clinical parameters that affect therapeutic outcome.
Methods: A total of 30 lesions in 12 patients with vitiligo were treated clinically with three fractional laser systems
with a four-week interval. Simultaneously, all patients were treated with narrow-band UVB (NBUVB) light twice a
week. The pigmentation rates were graded based on the use of a five-point scale by a dermatologist. We also
investigated the patient satisfaction level and compared the pigmentation rates of the lesions treated with a fractional
laser plus NBUVB with control areas treated only with NBUVB. In addition, we analyzed the mean grade of
pigment induction for various therapeutic and clinical parameters.
Results: A total of 30 lesions were treated with a fractional laser. The pigmentation grade and satisfaction score
were higher in the areas treated with a fractional laser, especially with an Nd:YAG fractional laser, as compared to
the control areas. The degree of pigmentation was better achieved for small-sized lesions (＜2 ㎠). Other clinical
parameters that affected the therapeutic outcome were the duration of vitiligo and the existence of poliosis. However,
the anatomical location of lesions and the type of vitiligo did not affect the therapeutic outcome. No significant side
effects were observed.
Conclusion: A fractional laser system offers an increase of overall pigmentation with a minimal risk of discomfort
and side effects, especially for a small-sized patch of vitiligo without poliosis and for patients with vitiligo of a
short duration (less than one year).

영어초록

Background: Numerous modalities of treatment for vitiligo have been introduced and have been proposed; however,
treatment for vitiligo remains challenging with no adequate solution.
Objective: This study was designed to examine the capability of the use of a fractional laser to induce pigmentation
for vitiligo and to investigate the therapeutic and clinical parameters that affect therapeutic outcome.
Methods: A total of 30 lesions in 12 patients with vitiligo were treated clinically with three fractional laser systems
with a four-week interval. Simultaneously, all patients were treated with narrow-band UVB (NBUVB) light twice a
week. The pigmentation rates were graded based on the use of a five-point scale by a dermatologist. We also
investigated the patient satisfaction level and compared the pigmentation rates of the lesions treated with a fractional
laser plus NBUVB with control areas treated only with NBUVB. In addition, we analyzed the mean grade of
pigment induction for various therapeutic and clinical parameters.
Results: A total of 30 lesions were treated with a fractional laser. The pigmentation grade and satisfaction score
were higher in the areas treated with a fractional laser, especially with an Nd:YAG fractional laser, as compared to
the control areas. The degree of pigmentation was better achieved for small-sized lesions (＜2 ㎠). Other clinical
parameters that affected the therapeutic outcome were the duration of vitiligo and the existence of poliosis. However,
the anatomical location of lesions and the type of vitiligo did not affect the therapeutic outcome. No significant side
effects were observed.
Conclusion: A fractional laser system offers an increase of overall pigmentation with a minimal risk of discomfort
and side effects, especially for a small-sized patch of vitiligo without poliosis and for patients with vitiligo of a
short duration (less than one year).

참고자료

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