고호모시스테인혈증 임신 흰쥐에서 엽산보충이 혈장 호모시스테인, Thiobarbituric Acid Reactive Substances (TBARS)수준과 간의 SAM/SAH에 미치는 영향 (Effects of Folic Acid Supplementation on Plasma Homocysteine and Thiobarbituric Acid Reactive Substances (TBARS) Levels and Liver SAM/SAH Ratio in Hyperhomocysteinaemia-induced Pregnant Rats)

서지정보

· 발행기관 : 한국영양학회
· 수록지 정보 : Journal of Nutrition and Health / 38권 / 7호 / 495 ~ 502페이지
· 저자명 : 홍경주, 현태선, 장남수

초록

This study was performed to investigate effects of dietary folic acid supplementation on plasma homocysteine levels,thiobarbituric acid reactive substances (TBARS) levels and liver SAM/SAH ratio in hyperhomocysteinaemia-inducedpregnant rats. Forty-two female Sprague-Dawley rats were divided three groups (C: control diet, HFD: 0.3% homocystineand 0 mg folic acid diet, HFS: 0.3 % homocystine and 8 mg/kg folic acid diet) according to homocystine and folicacid levels in the diet. They were fed experimental diets for 5 weeks prior to the mating and also during the entireperiod of pregnancy till gestational day 20. Dietary folic acid supplementation caused a significant decrease in plasmahomocysteine levels which had been increased by a homocystine-diet, with a concomitant increase in plasma and liverfolate levels. Liver TBARS levels in homocysteine-folic acid- deficient group (HFD) were higher than those in controlgroup. Dietary folic acid supplementation increased hepatic SAM/SAH ratio in homocysteine-folic acid- supplemetantiongroup (HFS) when compared to the HFD (p < 0.05). These data suggest that folate depletion and elevated plasmahomocysteine may promote oxidative stress in rat livers and influence the remethylation cycle of the homocysteine metabolismdetrimentally. In conclusion, dietary folic acid supplementation was found to be effective for lowering plasmahomocysteine levels, relieving oxidative stress, and improving the methylation status in the body. (Korean J Nutrition38(7): 495 ~ 502, 2005)

영어초록

This study was performed to investigate effects of dietary folic acid supplementation on plasma homocysteine levels,thiobarbituric acid reactive substances (TBARS) levels and liver SAM/SAH ratio in hyperhomocysteinaemia-inducedpregnant rats. Forty-two female Sprague-Dawley rats were divided three groups (C: control diet, HFD: 0.3% homocystineand 0 mg folic acid diet, HFS: 0.3 % homocystine and 8 mg/kg folic acid diet) according to homocystine and folicacid levels in the diet. They were fed experimental diets for 5 weeks prior to the mating and also during the entireperiod of pregnancy till gestational day 20. Dietary folic acid supplementation caused a significant decrease in plasmahomocysteine levels which had been increased by a homocystine-diet, with a concomitant increase in plasma and liverfolate levels. Liver TBARS levels in homocysteine-folic acid- deficient group (HFD) were higher than those in controlgroup. Dietary folic acid supplementation increased hepatic SAM/SAH ratio in homocysteine-folic acid- supplemetantiongroup (HFS) when compared to the HFD (p < 0.05). These data suggest that folate depletion and elevated plasmahomocysteine may promote oxidative stress in rat livers and influence the remethylation cycle of the homocysteine metabolismdetrimentally. In conclusion, dietary folic acid supplementation was found to be effective for lowering plasmahomocysteine levels, relieving oxidative stress, and improving the methylation status in the body. (Korean J Nutrition38(7): 495 ~ 502, 2005)

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