흰쥐 유양동 폐쇄술에 사용한 Hydroxyapatite Cement와 Demineralized Bone Matrix의 효과 및 조직병리학적 비교 연구 (Histopathologic Study on the Obliteration of the Temporal Dorsal Bullae in Rat Using Hydroxyapatite Cement and Demineralized Bone Matrix)

서지정보

· 발행기관 : 대한이비인후과학회
· 수록지 정보 : 대한이비인후-두경부외과학회지 / 51권 / 9호 / 777 ~ 782페이지
· 저자명 : 구태우, 장윤석, 김소향, 김수진, 홍숙희, 강명구

초록

Mastoid obliteration surgery is a useful technique for otitis media either with or without cholesteatoma.
Obliterating materials have to satisfy low antigenecity, less inflammation, little tissue resorption, high regeneration
power and good integration into the host tissue. The aim of our study is to evaluate histopathological changes and effectiveness
resulting from the different obliterating materials in the temporal dorsal bullae in rats. Materials and Method：We divided the
rats into two groups. Group A was untreated, but group B underwent removal of mastoid mucosa with 2% trichloroacetic acid
(TCA). Both groups had mastoid obliteration by the implantation of hydroxyapatite cement (Mimix®) and demineralized bone
matrix (Regenafil®). Twelve weeks after the implantation, a histological study was performed to evaluate remaining implanted
material, new bone formation and the formation of cysts within the bullae. Results：There was no or minimal inflammation or
foreign body reactions in the mastoid obliteration groups with Mimix® and Regenafil®. In the obliterated group that was not
treated with 2% TCA, the remaining implanted material with Mimix® group was more than in the Regenafil® group (p<0.05).
The obliterated groups of Mimix® and Regenafil® were similar with respect to new bone formation. The mucocele formation in
the obliterated groups treated with 2% TCA was less than in the obliterated groups not treated with 2% TCA (p<0.05).
Conclusion：We suggest that Mimix® and Regenafil® could be valuable resources as graft materials for mastoid obliteration
procedures. The research continues for evaluation of long term results of these materials and their potential as graft materials.
(Korean J Otorhinolaryngol-Head Neck Surg 2008;51:777-82)

영어초록

Mastoid obliteration surgery is a useful technique for otitis media either with or without cholesteatoma.
Obliterating materials have to satisfy low antigenecity, less inflammation, little tissue resorption, high regeneration
power and good integration into the host tissue. The aim of our study is to evaluate histopathological changes and effectiveness
resulting from the different obliterating materials in the temporal dorsal bullae in rats. Materials and Method：We divided the
rats into two groups. Group A was untreated, but group B underwent removal of mastoid mucosa with 2% trichloroacetic acid
(TCA). Both groups had mastoid obliteration by the implantation of hydroxyapatite cement (Mimix®) and demineralized bone
matrix (Regenafil®). Twelve weeks after the implantation, a histological study was performed to evaluate remaining implanted
material, new bone formation and the formation of cysts within the bullae. Results：There was no or minimal inflammation or
foreign body reactions in the mastoid obliteration groups with Mimix® and Regenafil®. In the obliterated group that was not
treated with 2% TCA, the remaining implanted material with Mimix® group was more than in the Regenafil® group (p<0.05).
The obliterated groups of Mimix® and Regenafil® were similar with respect to new bone formation. The mucocele formation in
the obliterated groups treated with 2% TCA was less than in the obliterated groups not treated with 2% TCA (p<0.05).
Conclusion：We suggest that Mimix® and Regenafil® could be valuable resources as graft materials for mastoid obliteration
procedures. The research continues for evaluation of long term results of these materials and their potential as graft materials.
(Korean J Otorhinolaryngol-Head Neck Surg 2008;51:777-82)

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