고지방식이 유도된 흰쥐에서 고강도 운동과 DA-9601의 투여가 혈중지질에 미치는 영향 (The effect of DA-9601 and high-intensity exercise on blood lipid in high fat diet rats.)

서지정보

· 발행기관 : 한국체육과학회
· 수록지 정보 : 한국체육과학회지 / 21권 / 4호 / 1427 ~ 1439페이지
· 저자명 : 최진경, 최은주

초록

The purpose of this study was to investigate the effects of High intensity exercise and DA-9601 administration on blood lipid in high fat diet rats. Male Sprague Dawley rats were randomly divided into 4 groups; control(CON, n=7), high intensity exercise group(EXE, n=7), DA-9601 group(DA, n=7) high intensity exercise plus DA-9601 group(DAE, n=7). Animals were given an oral injection of DA-9601 with 50 mg of dosage per kg for four weeks. In order to induce EXE animals were allowed to ran on a treadmill with 7 degree of slope at speed of 28m/min for 36 minutes. The exercise was performed five times a week for 4 week. The results of this study were as following; The food intake and organ weights of DAE group were significantly lower than that of CON group(p<.05). The body weight of four groups increased throughout the experimental period, whereas that of the DAE group decreased after 4wk. The plasma triglyceride and total cholesterol, LDL-C levels of DAE group were significantly lower than that of the other groups(p<.05). HDL-cholesterol/total cholesterol(%) levels of DA and DAE groups were markedly higher than that of the other groups(p<.05). In conclusion, the data obtained in this study suggest that high intensity exercise and DA-9601 administration improve the hyperlipidemia in rats.

영어초록

The purpose of this study was to investigate the effects of High intensity exercise and DA-9601 administration on blood lipid in high fat diet rats. Male Sprague Dawley rats were randomly divided into 4 groups; control(CON, n=7), high intensity exercise group(EXE, n=7), DA-9601 group(DA, n=7) high intensity exercise plus DA-9601 group(DAE, n=7). Animals were given an oral injection of DA-9601 with 50 mg of dosage per kg for four weeks. In order to induce EXE animals were allowed to ran on a treadmill with 7 degree of slope at speed of 28m/min for 36 minutes. The exercise was performed five times a week for 4 week. The results of this study were as following; The food intake and organ weights of DAE group were significantly lower than that of CON group(p<.05). The body weight of four groups increased throughout the experimental period, whereas that of the DAE group decreased after 4wk. The plasma triglyceride and total cholesterol, LDL-C levels of DAE group were significantly lower than that of the other groups(p<.05). HDL-cholesterol/total cholesterol(%) levels of DA and DAE groups were markedly higher than that of the other groups(p<.05). In conclusion, the data obtained in this study suggest that high intensity exercise and DA-9601 administration improve the hyperlipidemia in rats.

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