로얄제리 섭취가 UV로 손상된 무모쥐의 피부조직에 미치는 항산화 효과 (Effect of Royal Jelly Intake on Antioxidant Activity in the Skin of Mice after UV Irradiation)

서지정보

· 발행기관 : 대한암예방학회
· 수록지 정보 : 대한암예방학회지 / 15권 / 3호 / 217 ~ 224페이지
· 저자명 : 서보영, 박은주, 이광길, 한상미, 최유연, 조윤희, 박유경

초록

Royal jelly is a honey bee secretion that is used in the nutrition of the larvae. It has been reported to contain remarkable amounts of proteins, lipids, vitamins, hormones, enzymes, mineral substances, and specific vital factors that act as biocatalysts in cell regeneration processes within the human body. This study was designed to study the effect of royal jelly on ultraviolet (UV) induced skin damage. Three kinds of Korean and one Chinese royal jelly (GP: Gimpo, PC: Pochoen, CW: Cholwon, CH: China.)was supplemented to mice after UV-irradiation, SKH hairless female mice were fed 1% royal jelly and irradiated with UV for six weeks. The amount of retinol was measured in the mice dermis and epidermis.
The effect of royal jelly on epidermis was not significantly different among groups but were significantly higher than UV＋ and UV－ group. Catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase was measured in both dermis and epidermis. CAT and GSH-Px activity was not significantly different among groups in the dermis, but, SOD level was significantly higher (p＜0.05) in the PC, CW,CH group. The degree of endogenous DNA damage (assessed by tail DNA, tail length and tail moment)was significantly increased after UV irradiation, but, royal jelly decreased the degree of DNA damage in all groups. H2O2 induced DNA damage was also increased in the UV irradiated mice, but, supplementation of royal jelly reduced the DNA damage to the level of un-irradiated mice. Putting these together,these result demonstrate that royal jelly consumption for 6weeks with UV irradiation seems to have a partial antioxidant capacity.

영어초록

Royal jelly is a honey bee secretion that is used in the nutrition of the larvae. It has been reported to contain remarkable amounts of proteins, lipids, vitamins, hormones, enzymes, mineral substances, and specific vital factors that act as biocatalysts in cell regeneration processes within the human body. This study was designed to study the effect of royal jelly on ultraviolet (UV) induced skin damage. Three kinds of Korean and one Chinese royal jelly (GP: Gimpo, PC: Pochoen, CW: Cholwon, CH: China.)was supplemented to mice after UV-irradiation, SKH hairless female mice were fed 1% royal jelly and irradiated with UV for six weeks. The amount of retinol was measured in the mice dermis and epidermis.
The effect of royal jelly on epidermis was not significantly different among groups but were significantly higher than UV＋ and UV－ group. Catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase was measured in both dermis and epidermis. CAT and GSH-Px activity was not significantly different among groups in the dermis, but, SOD level was significantly higher (p＜0.05) in the PC, CW,CH group. The degree of endogenous DNA damage (assessed by tail DNA, tail length and tail moment)was significantly increased after UV irradiation, but, royal jelly decreased the degree of DNA damage in all groups. H2O2 induced DNA damage was also increased in the UV irradiated mice, but, supplementation of royal jelly reduced the DNA damage to the level of un-irradiated mice. Putting these together,these result demonstrate that royal jelly consumption for 6weeks with UV irradiation seems to have a partial antioxidant capacity.

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