적출 쥐 심장에서 Nicorandil과 Verapamil의 혼합투여가 심장 허혈/재관류에 미치는 영향 (Myocardial protective effects of nicorandil and verapamil during ischemia-reperfusion in an isolated perfused rat heart)

서지정보

· 발행기관 : 대한마취통증의학회
· 수록지 정보 : Anesthesia and Pain Medicine / 3권 / 4호 / 270 ~ 276페이지
· 저자명 : 김형섭

초록

Background: To reduce or prevent myocardial injury during an
ischemia-reperfusion episode, some pharmacological interventions,
including administering nicorandil or verapamil, have become
popular in clinical situations. Nicorandil is a N-(2-hydroxyethyl)-
nicotinamide nitrate ester, and it’s effective mainly by opening the
K＋
ATP channels in the mitochondrial membrane, and verapamil is
useful for reducing the endothelial injury of coronary vessels during
ischemia. In this study, we aimed to determine the cardioprotective
effect when both drugs are used simultaneously.
Methods: Isolated rat hearts (the Langendorff perfusion model)
were perfused with Krebs-Henseleit bicarbonate buffer. After 30
minutes of controlled perfusion, we added nicorandil or verapamil
separately and both drugs were administered together in another
group (the mixed group) and we then induced ischemia for 30
minutes. We measured the heart rate, the developed ventricularpressure
and the dP/dT during the control period during drug
infusion and during reperfusion at 15, 30, 45 and 60 minutes.
Results: During reperfusion, the mixed group showed more
favorable results for the developed left ventricular pressure (LVP),
the dP/dT and the rate pressure product (RPP). The heart rate
was significantly decreased as reperfusion processed in all the
groups.
Conclusions: For myocardial protection during ischemia-reperfusion,
a mixed drug regimen is more beneficial than a single drug
regimen, and this occurs without inducing a significant decrease of
the heart rate.

영어초록

Background: To reduce or prevent myocardial injury during an
ischemia-reperfusion episode, some pharmacological interventions,
including administering nicorandil or verapamil, have become
popular in clinical situations. Nicorandil is a N-(2-hydroxyethyl)-
nicotinamide nitrate ester, and it’s effective mainly by opening the
K＋
ATP channels in the mitochondrial membrane, and verapamil is
useful for reducing the endothelial injury of coronary vessels during
ischemia. In this study, we aimed to determine the cardioprotective
effect when both drugs are used simultaneously.
Methods: Isolated rat hearts (the Langendorff perfusion model)
were perfused with Krebs-Henseleit bicarbonate buffer. After 30
minutes of controlled perfusion, we added nicorandil or verapamil
separately and both drugs were administered together in another
group (the mixed group) and we then induced ischemia for 30
minutes. We measured the heart rate, the developed ventricularpressure
and the dP/dT during the control period during drug
infusion and during reperfusion at 15, 30, 45 and 60 minutes.
Results: During reperfusion, the mixed group showed more
favorable results for the developed left ventricular pressure (LVP),
the dP/dT and the rate pressure product (RPP). The heart rate
was significantly decreased as reperfusion processed in all the
groups.
Conclusions: For myocardial protection during ischemia-reperfusion,
a mixed drug regimen is more beneficial than a single drug
regimen, and this occurs without inducing a significant decrease of
the heart rate.

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