유산소운동이 제1형 당뇨쥐의 망막조직세포 미토콘드리아MnSOD 활성에 미치는 영향 (Effects of Aerobic Exercise on Mitochondrial MnSOD Activity of Retinol Tissue Cells in the Type 1 Diabetic Rats)

서지정보

· 발행기관 : 한국생활환경학회
· 수록지 정보 : 한국생활환경학회지 / 20권 / 7호 / 919 ~ 927페이지
· 저자명 : 윤성진, 박진훈, 윤진환

초록

We examined the effect of an aerobic exercise on the MnSOD antioxidants expression of retinal cytosoland retinal mitochondria in streptozotocin-induced diabetic rats. To achieve the purpose of this study, Male Sprague-Dawley rats (7 weeks of age) were divided into four groups (n=10 in each group): the diabetic control group(=A),diabetic low intensity exercise (6~8m min−1) group(=B), diabetic mild intensity exercise (14~16m min−1) group(=C),and diabetic high intensity exercise (18~20m min−1) group(=D). All rats in the exercise group were forced to run ona treadmill for 30 min at 0 degree of inclination. Retinal cytosol was extracted from retinal tissue and retinal mitochondriawas purified from the retinal cytosol relative activity (%) of retinal cytosol MnSOD for control, low exercise,mild exercise and high exercise group showed the following order of prevalence : B > C > D > A. Also MnSODexpress in retinal mitochondria was B > C > D > A for moderate group. MnSOD expression was most significant inlow intensity exercise group of retinal cytosol and mitochondria(p<.01). Changes in the blood glucose of diabetic groupshowed significantly between exercise groups and low intensity exercise group showed the biggest change(P<.01). Thechanges in the insulin concentration of blood serum showed significantly between exercise groups and low intensityexercise group showed the highest concentration. The degree of HOMA-IR showed significantly between exercisegroups and positively correlated with exercise intensity(P<.01). The present data suggested that antioxidants are regulatedby exercise training. Thus antioxidants belong to a class of selected metabolic factors that were upregulated inexercise stimulus.

영어초록

We examined the effect of an aerobic exercise on the MnSOD antioxidants expression of retinal cytosoland retinal mitochondria in streptozotocin-induced diabetic rats. To achieve the purpose of this study, Male Sprague-Dawley rats (7 weeks of age) were divided into four groups (n=10 in each group): the diabetic control group(=A),diabetic low intensity exercise (6~8m min−1) group(=B), diabetic mild intensity exercise (14~16m min−1) group(=C),and diabetic high intensity exercise (18~20m min−1) group(=D). All rats in the exercise group were forced to run ona treadmill for 30 min at 0 degree of inclination. Retinal cytosol was extracted from retinal tissue and retinal mitochondriawas purified from the retinal cytosol relative activity (%) of retinal cytosol MnSOD for control, low exercise,mild exercise and high exercise group showed the following order of prevalence : B > C > D > A. Also MnSODexpress in retinal mitochondria was B > C > D > A for moderate group. MnSOD expression was most significant inlow intensity exercise group of retinal cytosol and mitochondria(p<.01). Changes in the blood glucose of diabetic groupshowed significantly between exercise groups and low intensity exercise group showed the biggest change(P<.01). Thechanges in the insulin concentration of blood serum showed significantly between exercise groups and low intensityexercise group showed the highest concentration. The degree of HOMA-IR showed significantly between exercisegroups and positively correlated with exercise intensity(P<.01). The present data suggested that antioxidants are regulatedby exercise training. Thus antioxidants belong to a class of selected metabolic factors that were upregulated inexercise stimulus.

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