玄蔘丹蔘飮이 Monocrotaline으로 유발된 고혈압 흰쥐에 미치는 영향 (Effect of Hyeonsamdansameum on Hypertensive Rat Induced Monocrotaline)

서지정보

· 발행기관 : 한의병리학회
· 수록지 정보 : 동의생리병리학회지 / 22권 / 5호 / 1223 ~ 1235페이지
· 저자명 : 강철식, 전상윤, 홍석

초록

This experiment was performed to investigate the effects of Hyeonsamdansameum(HDE) on hypertension. For the study of HDE, we had divided Sprague-Dawley rats to three groups-normal, control, HDE. The control group was injected subcutaneous with monocrotaline(50 ㎎/㎏). The treatment group was injected subcutaneous with monocrotaline(50 ㎎/㎏) and orally administered with HDE extract for 4 weeks(once a day, 208 ㎎/㎏). Then we measured blood pressure, heart rate, on the plasma aldosterone, catecholamine, electrolyte, uric acid, BUN, creatinine, and observed the lung, cardiac muscle, liver, etc. The results of these were as follows: 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and superoxide dismutase(SOD) - like activity were increased, reactive oxygen species (ROS) was decreased. Angiotensin converting enzyme(ACE) inhibitory activity was increased in a concentration - dependent by HDE. HDE significantly increased body weight in monocrotaline hypertensive rat, so supported nearly normal group. HDE significantly decreased blood pressure and heart rate in monocrotaline hypertensive rat. HDE significantly decreased aldosterone in adrenocortical hormones. HDE significantly decreased dopamine, norepinephrine, epinephrine. Na+, Cl- were intended to decrease, K+ was decreased significantly by HDE. Uric acid, BUN were significantly decreased and creatinine was intended to decrease by HDE. HDE inhibited lung, liver and heart injury connected with hypertension. These results suggest that HDE is usefully applied in treatment and prevention of hypertension.

영어초록

This experiment was performed to investigate the effects of Hyeonsamdansameum(HDE) on hypertension. For the study of HDE, we had divided Sprague-Dawley rats to three groups-normal, control, HDE. The control group was injected subcutaneous with monocrotaline(50 ㎎/㎏). The treatment group was injected subcutaneous with monocrotaline(50 ㎎/㎏) and orally administered with HDE extract for 4 weeks(once a day, 208 ㎎/㎏). Then we measured blood pressure, heart rate, on the plasma aldosterone, catecholamine, electrolyte, uric acid, BUN, creatinine, and observed the lung, cardiac muscle, liver, etc. The results of these were as follows: 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and superoxide dismutase(SOD) - like activity were increased, reactive oxygen species (ROS) was decreased. Angiotensin converting enzyme(ACE) inhibitory activity was increased in a concentration - dependent by HDE. HDE significantly increased body weight in monocrotaline hypertensive rat, so supported nearly normal group. HDE significantly decreased blood pressure and heart rate in monocrotaline hypertensive rat. HDE significantly decreased aldosterone in adrenocortical hormones. HDE significantly decreased dopamine, norepinephrine, epinephrine. Na+, Cl- were intended to decrease, K+ was decreased significantly by HDE. Uric acid, BUN were significantly decreased and creatinine was intended to decrease by HDE. HDE inhibited lung, liver and heart injury connected with hypertension. These results suggest that HDE is usefully applied in treatment and prevention of hypertension.

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