흰쥐에서 지구자 추출물의 에탄올 유도 숙취 행동 개선 효능 (The Ameliorating Effect of Hoveniae Semen Seu Fructus Extract against Ethanol-induced Psychomotor Alterations in Rats)

서지정보

· 발행기관 : 대한약학회
· 수록지 정보 : 약 학 회 지 / 58권 / 5호 / 300 ~ 306페이지
· 저자명 : 어이린조이델라페나, 준브라이언델라페나, 정재훈

초록

Ethanol consumption causes psychomotor alterations. Hovenia Semen seu Fructus (HS), widely distributed inKorea, China, and Japan, has been reported to have beneficial effects on acute alcohol-induced liver injury. The present studysought to assess the effects of HS extract on ethanol-induced psychomotor alterations in rats. Sprague-Dawley rats wereorally (p.o.) given ethanol (4 g/kg) (ethanol group) to induce psychomotor alterations. A separate group (HS-treated groups),were treated with different dosages of HS (50, 100, and 200 mg/kg, p.o.), 30 minutes before ethanol treatment. The controlgroup received only the vehicle (saline). Ethanol-induced psychomotor alterations were evaluated in the open-field, rota-rod,hanging wire, and cold swimming test. In addition, blood ethanol and acetaldehyde concentrations were also measured. Behavioral evaluations and blood analysis were carried out 0.5, 1, 2, 4, and 8 hours after ethanol administration. Pre-treatmentof HS ameliorated ethanol-induced alterations in the open-field, rota-rod, and cold swimming test, significantly evidentin 2 and 4 hours after ethanol treatment. These improvements coincided with decrease in blood ethanol and acetaldehydeconcentration. Based on these results, the present study suggests that HS may have ameliorating effects against ethanolinducedpsychomotor alterations

영어초록

Ethanol consumption causes psychomotor alterations. Hovenia Semen seu Fructus (HS), widely distributed inKorea, China, and Japan, has been reported to have beneficial effects on acute alcohol-induced liver injury. The present studysought to assess the effects of HS extract on ethanol-induced psychomotor alterations in rats. Sprague-Dawley rats wereorally (p.o.) given ethanol (4 g/kg) (ethanol group) to induce psychomotor alterations. A separate group (HS-treated groups),were treated with different dosages of HS (50, 100, and 200 mg/kg, p.o.), 30 minutes before ethanol treatment. The controlgroup received only the vehicle (saline). Ethanol-induced psychomotor alterations were evaluated in the open-field, rota-rod,hanging wire, and cold swimming test. In addition, blood ethanol and acetaldehyde concentrations were also measured. Behavioral evaluations and blood analysis were carried out 0.5, 1, 2, 4, and 8 hours after ethanol administration. Pre-treatmentof HS ameliorated ethanol-induced alterations in the open-field, rota-rod, and cold swimming test, significantly evidentin 2 and 4 hours after ethanol treatment. These improvements coincided with decrease in blood ethanol and acetaldehydeconcentration. Based on these results, the present study suggests that HS may have ameliorating effects against ethanolinducedpsychomotor alterations

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