제5기 국민건강영양조사 자료 중 남성에서 혈청 중 25-hydroxyvitamin D와 만성폐쇄성폐질환의 상관관계 (Relationship between serum 25-hydroxyvitamin D and chronic obstructive pulmonary disease in males in the fifth Korean national health and nutrition examination survey)

서지정보

· 발행기관 : 한국영양학회
· 수록지 정보 : Journal of Nutrition and Health / 47권 / 5호 / 321 ~ 329페이지
· 저자명 : 정인경

초록

제5기국민건강영양조사 자료중 40세이상 남성을 대상으로 혈액 중 25(OH)D와 COPD의 상관관계를 조사하였다. 25(OH)D는사분위로군을나누어적용하였고, 2012년개정된 진료지침에 따라 FEV1/FEV6 < 0.73인 경우를COPD로 판정하였다. 다른 요인을 보정하지 않았을 경우에는 25(OH)D와 COPD 사이에 상관관계가 없었으나 흡연상태, 가계소득, 교육수준, 직업, BMI, 만연령및흡연지수를 보정하였을 때는 25(OH)D와 COPD사이에 유의한상관관계를 보였다. 25(OH)D농도 17~21 ng/mL인 3/4분위군을 기준으로 1/4분위의 경우의 OR 1.643 (95% CI 1.161-2.236), 2/4분위는 OR 1.453 (95% CI 1.045-2.020) 으로 유의하게 증가하였다. 결론적으로 40세 이상 남성에서 혈중 25(OH)D 농도는 COPD 유병가능성과 유의한 상관관계를보였다. 즉, 3/4 분위군 [25(OH)D 17 ng/mL 이상21 ng/mL 미만]을 기준으로 혈중농도가 낮을수록 COPD 유병가능성이높았다.

영어초록

Purpose: The aim of this study was to determine the relationship between serum concentrations of 25-hydroxyvitamin D[25(OH)D] and chronic obstructive pulmonary disease (COPD) prevalence. Methods: The analysis was performed usingdata from the Fifth Korean National Health and Nutrition Examination Survey, a cross-sectional survey of the Korean civilianpopulation conducted from 2010 to 2012. The analyses were restricted to males who were 40 years of age and above.
Complex sample multiple logistic regression analyses were used to examine the associations of COPD prevalence with25(OH)D and other factors. Results: FEV1/FEV6 varied significantly with smoking status, age, household income, educationlevel, occupation, body mass index (BMI), and physical activity (p < 0.05). In univariate analysis, smoking status, BMI,household income, education level, and occupation showed association with COPD (p < 0.05), but vitamin D was notassociated with COPD (p = 0.078). However, when adjusted with smoking status, household income, education level,occupation, BMI, age, and smoking index, the lowest quartile of 25(OH)D showed OR 1.643 (95% CI 1.161-2.236) comparedto 3rd quartile (p = 0.024). Conclusion: A significant relationship was observed between serum concentration of 25(OH)Dand COPD.

참고자료

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