위식도역류질환에서 1주 Esomeprazole 치료의 진단적 의의 (Diagnostic Significance of One-week Esomeprazole Treatment in Gastro-esophageal Reflux Disease)

서지정보

· 발행기관 : 대한소화기 기능성질환∙운동학회
· 수록지 정보 : Journal of Neurogastroenterology and Motility (JNM) / 14권 / 2호 / 88 ~ 95페이지
· 저자명 : 정훈용, 정기욱, 허규찬, 지삼룡, 최석채, 이준행, 이인석, 이용찬, 이광재, 심기남, 박형석, 박효진

초록

Background/Aims: Gastroesophageal reflux disease (GERD) can be diagnosed by symptoms, endoscopic findings, and pH monitoring. Endoscopic findings and pH monitoring have high specificity and low sensitivity. Since medical fees for the symptom-based treatment are not fully covered by insurance in Korea, endoscopy and pH monitoring are mainly being performed to prove GERD. We aimed to investigate the sensitivity of one-week PPI test in diagnosing GERD
in patients with typical reflux symptoms. Patients/Methods: Patients complaining of typical symptom over twice/week were enrolled and esomeprazole (40 mg) was prescribed for one week. Frequency and severity of symptoms were analyzed and sensitivity of PPI test was calculated. GERD group was defined as having erosive esophagitis or a positive pH test. Positive rates of PPI test were calculated in GERD and non-GERD groups. Results: A total of 103 patients from 11 hospitals were enrolled, and 100 of them completed until the end of the study. Seventy-nine patients reached symptomatic improvement after one-week (positive PPI test), and positive rates were 84.3% (70/83) in GERD group and 52.9% (9/17) in non-GERD, respectively (p<0.05). Conclusions: The sensitivity of PPI test in diagnosing GERD in symptomatic patients was 84.3%, and this test is considered to have diagnostic value for GERD.

영어초록

Background/Aims: Gastroesophageal reflux disease (GERD) can be diagnosed by symptoms, endoscopic findings, and pH monitoring. Endoscopic findings and pH monitoring have high specificity and low sensitivity. Since medical fees for the symptom-based treatment are not fully covered by insurance in Korea, endoscopy and pH monitoring are mainly being performed to prove GERD. We aimed to investigate the sensitivity of one-week PPI test in diagnosing GERD
in patients with typical reflux symptoms. Patients/Methods: Patients complaining of typical symptom over twice/week were enrolled and esomeprazole (40 mg) was prescribed for one week. Frequency and severity of symptoms were analyzed and sensitivity of PPI test was calculated. GERD group was defined as having erosive esophagitis or a positive pH test. Positive rates of PPI test were calculated in GERD and non-GERD groups. Results: A total of 103 patients from 11 hospitals were enrolled, and 100 of them completed until the end of the study. Seventy-nine patients reached symptomatic improvement after one-week (positive PPI test), and positive rates were 84.3% (70/83) in GERD group and 52.9% (9/17) in non-GERD, respectively (p<0.05). Conclusions: The sensitivity of PPI test in diagnosing GERD in symptomatic patients was 84.3%, and this test is considered to have diagnostic value for GERD.

참고자료

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