관상동맥 질환의 중재시술 후에 측정한 Thrombolysis in Myocardial Infarction Frame Count에 따른 좌심실 수축기능의 변화 (Changes in Left Ventricular Systolic Function According to Thrombolysis in Myocardial Infarction Frame Count Immediately After Coronary Intervention in Patients With Obstructive Coronary Artery Diseas)

서지정보

· 발행기관 : 대한심장학회
· 수록지 정보 : Korean Circulation Journal / 38권 / 12호 / 666 ~ 670페이지
· 저자명 : 김현중, 한성우, 김성해, 서순용, 정상만, 유규형

초록

Background and Objectives: Some reports have suggested that coronary microvascular dysfunction plays a role in
the recovery of myocardial function in patients with obstructive coronary artery disease. Thrombolysis in myocardial
infarction (TIMI) frame count (TFC) is regarded as a simple, reliable method for evaluating microvascular
function. We evaluated microvascular function using TFC immediately after coronary intervention and compared
TFC with left ventricular systolic function eight months later. Subjects and Methods: We studied 68 patients
with obstructive coronary artery disease who underwent coronary intervention. Just after intervention, TFC was
calculated with the standard method. Left ventricular systolic function was assessed with left ventricular diastolic
dimension (LVEDd), ejection fraction (EF), and wall motion score index (WMSI). Eight months after intervention,
we completed follow-up coronary angiography and echocardiography. We defined high TFC (HTFC) as a
TFC greater than 18. Results: Ten patients were in the HTFC group, and 58 patients were in the low TFC (LTFC)
group. There was no difference between the two groups with regard to baseline cardiovascular characteristics and
angiographic findings. Just after intervention, the HTFC group showed significantly higher LVEDd (56.6±8.9
mm) and WMSI (1.60±0.65) compared to the LTFC group (50.3±5.9 mm, p<0.05; 1.34±0.29, p<0.05, respectively),
but there was no significant difference in EF between the groups (49.3±18.6% vs. 56.2±14.8%, p>
0.05). Eight months after intervention, there was also a significant decrease in the WMSI in the LTFC group
(1.23±0.25, p<0.05), but not in the HTFC group (1.57±0.62, p>0.05). Conclusion: Increased TFC immediately
after coronary intervention is an important poor prognostic factor related to myocardial systolic function eight
months after coronary intervention. Coronary microvascular dysfunction may influence myocardial recovery in
the setting of obstructive coronary artery disease.

영어초록

Background and Objectives: Some reports have suggested that coronary microvascular dysfunction plays a role in
the recovery of myocardial function in patients with obstructive coronary artery disease. Thrombolysis in myocardial
infarction (TIMI) frame count (TFC) is regarded as a simple, reliable method for evaluating microvascular
function. We evaluated microvascular function using TFC immediately after coronary intervention and compared
TFC with left ventricular systolic function eight months later. Subjects and Methods: We studied 68 patients
with obstructive coronary artery disease who underwent coronary intervention. Just after intervention, TFC was
calculated with the standard method. Left ventricular systolic function was assessed with left ventricular diastolic
dimension (LVEDd), ejection fraction (EF), and wall motion score index (WMSI). Eight months after intervention,
we completed follow-up coronary angiography and echocardiography. We defined high TFC (HTFC) as a
TFC greater than 18. Results: Ten patients were in the HTFC group, and 58 patients were in the low TFC (LTFC)
group. There was no difference between the two groups with regard to baseline cardiovascular characteristics and
angiographic findings. Just after intervention, the HTFC group showed significantly higher LVEDd (56.6±8.9
mm) and WMSI (1.60±0.65) compared to the LTFC group (50.3±5.9 mm, p<0.05; 1.34±0.29, p<0.05, respectively),
but there was no significant difference in EF between the groups (49.3±18.6% vs. 56.2±14.8%, p>
0.05). Eight months after intervention, there was also a significant decrease in the WMSI in the LTFC group
(1.23±0.25, p<0.05), but not in the HTFC group (1.57±0.62, p>0.05). Conclusion: Increased TFC immediately
after coronary intervention is an important poor prognostic factor related to myocardial systolic function eight
months after coronary intervention. Coronary microvascular dysfunction may influence myocardial recovery in
the setting of obstructive coronary artery disease.

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