유방암환자에서 Tc-99m sulfur colloid 및 Methylene blue dye를 이용한 감시 림프절 생검의 임상적 유용성 (Clinical efficacy of sentinel lymph node biopsy using Tc-99m sulfur colloid and Methylene blue dye in breast cancer patients.)

서지정보

· 발행기관 : 고신대학교(의대) 고신대학교 의과대학 학술지
· 수록지 정보 : 고신대학교 의과대학 학술지 / 21권 / 2호 / 82 ~ 88페이지
· 저자명 : 최우식, 전창완, 이충한

초록

Background : The status of the axillary nodes in breast carcinoma patients is one of the most significant prognosis factors. Sentinel lymph node biopsy is an useful method for assessing axillary nodal status and selecting axillary dissection in breast cancer patients. We evaluated the detection rate, sensitivity, accuracy, false negative rate, and negative prediction value of sentinel node biopsy using technetium radiolabeled sulfur colloid and methylene blue dye.
Methods : Sentinel lymphadenectomy followed by axillary lymph node dissection was performed in 45 patients with invasive breast carcinoma from Department of Surgery at Kosin University Gospel Hospital between December 2004 and June 2005. Tc-99m sulfur colloid and methylene blue dye was used in the detection of the sentinel lymph node with a gamma probe in the operating room.
Results : The detection rate of sentinel lymph node was 89% (40 of 45 patients), the sensitivity 89% (15/17), the accuracy 95% (38/40), and false negative rate 12% (2/17), and the negative predictive value 92% (23/25).
Conclusion : Sentinel lymph node biopsy was more effective when combination of technetium radiolabeled sulfur colloid and methylene blue dye were used. In the future, sentinel lymphadenectomy may replace axillary lymph node dissection in certain subgroups of breast carcinoma patients.

영어초록

Background : The status of the axillary nodes in breast carcinoma patients is one of the most significant prognosis factors. Sentinel lymph node biopsy is an useful method for assessing axillary nodal status and selecting axillary dissection in breast cancer patients. We evaluated the detection rate, sensitivity, accuracy, false negative rate, and negative prediction value of sentinel node biopsy using technetium radiolabeled sulfur colloid and methylene blue dye.
Methods : Sentinel lymphadenectomy followed by axillary lymph node dissection was performed in 45 patients with invasive breast carcinoma from Department of Surgery at Kosin University Gospel Hospital between December 2004 and June 2005. Tc-99m sulfur colloid and methylene blue dye was used in the detection of the sentinel lymph node with a gamma probe in the operating room.
Results : The detection rate of sentinel lymph node was 89% (40 of 45 patients), the sensitivity 89% (15/17), the accuracy 95% (38/40), and false negative rate 12% (2/17), and the negative predictive value 92% (23/25).
Conclusion : Sentinel lymph node biopsy was more effective when combination of technetium radiolabeled sulfur colloid and methylene blue dye were used. In the future, sentinel lymphadenectomy may replace axillary lymph node dissection in certain subgroups of breast carcinoma patients.

참고자료

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