1일 완전수면박탈 후 주간 졸음에 대한 Modafinil의 효과 (Modafinil Reversal on Daytime Sleepiness Induced by Sleep Deprivation)

서지정보

· 발행기관 : 대한생물치료정신의학회
· 수록지 정보 : 생물치료정신의학 / 15권 / 1호 / 51 ~ 63페이지
· 저자명 : 이동준, 왕성근, 이준, 이태경

초록

Objectives：The aim of this study was to investigate the effect of modafinil on daytime sleepiness and cognitive
dysfuntion induced by sleep deprivation.
Methods：In this study, 13 healthy young male subjects were examined under following conditions , after normal
usual sleep, one night sleep deprivation, one night sleep deprivation followed by 200mg of modafinil ingestion. Subjects
visited our laboratory by 08：00 at the first day, and they had baseline multiple sleep latency test(MSLT), and
Vienna Test(at 9：00, 11：00, 14：00, and 16：00). Each time. the subjects completed VAS for sleepiness, fatigue,
and mood before they underwent an Vienna Test to evaluate their attention, performance, and reaction. They had
one night sleep deprivation followed by 200mg of modafinil ingestion and repeated the same process as those of
the first day.
Results：After one night total sleep deprivation followed by 200mg of modafinil ingestion, subjective daytime
sleepiness, fatigue, and unpleasant mood caused by sleep deprivation were improved, but not to the level of baseline.
Increased objective sleepiness measured as sleep latency and total sleep time by MSLT was improved almost
to the level of baseline. Impaired continuous attention by sleep deprivation were improved to near those level of
baseline. But 200mg of modafinil was not effective for work performance and reaction time.
Conclusion：Not only for those with sleep disorder but also for normal person undergoing sleep deprivation, modafinil
is effective for improving sleepiness and fatigue. But additional studies are needed to establish effect of modafinil
to attention and performance.

영어초록

Objectives：The aim of this study was to investigate the effect of modafinil on daytime sleepiness and cognitive
dysfuntion induced by sleep deprivation.
Methods：In this study, 13 healthy young male subjects were examined under following conditions , after normal
usual sleep, one night sleep deprivation, one night sleep deprivation followed by 200mg of modafinil ingestion. Subjects
visited our laboratory by 08：00 at the first day, and they had baseline multiple sleep latency test(MSLT), and
Vienna Test(at 9：00, 11：00, 14：00, and 16：00). Each time. the subjects completed VAS for sleepiness, fatigue,
and mood before they underwent an Vienna Test to evaluate their attention, performance, and reaction. They had
one night sleep deprivation followed by 200mg of modafinil ingestion and repeated the same process as those of
the first day.
Results：After one night total sleep deprivation followed by 200mg of modafinil ingestion, subjective daytime
sleepiness, fatigue, and unpleasant mood caused by sleep deprivation were improved, but not to the level of baseline.
Increased objective sleepiness measured as sleep latency and total sleep time by MSLT was improved almost
to the level of baseline. Impaired continuous attention by sleep deprivation were improved to near those level of
baseline. But 200mg of modafinil was not effective for work performance and reaction time.
Conclusion：Not only for those with sleep disorder but also for normal person undergoing sleep deprivation, modafinil
is effective for improving sleepiness and fatigue. But additional studies are needed to establish effect of modafinil
to attention and performance.

참고자료

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