일개 농촌지역의 초등학생과 주민에서 다환성 방향족 탄화수소와 톨루엔 노출이 요중 Thiobarbituric Acid Reactive Substance 농도에 미치는 영향 (Effects of the Exposure to Polycyclic Aromatic Hydrocarbon or Toluene on Thiobarbituric Acid Reactive Substance Level in Elementary School Children and Elderlies in a Rural Area)

서지정보

· 발행기관 : 대한예방의학회
· 수록지 정보 : 예방의학회지 / 41권 / 1호 / 61 ~ 67페이지
· 저자명 : 김대선, 이철호, 엄상용, 강택신, 김용대, 김헌

초록

Objectives : Polycyclic aromatic hydrocarbons (PAH) and
toluene have been reported to induce reactive oxygen
species and oxidative stress. This study was performed to
investigate the effects of low level exposure to PAHs or
toluene on the lipid peroxidation level in elementary school
children and the elderly in a rural area.
Methods : Forty seven elementary school children and 40
elderly people who were living in a rural area and not
occupationally exposed to PAH or toluene were the
subjects of this study. Information about active or passive
smoking and diet was obtained using a self-administered
questionnaire. The urinary 1-hydroxypyrene (1-OHP), 2-
naphthol, hippuric acid and thiobarbituric acid reactive
substance (TBARS) concentrations were measured, and
these values were corrected with the urinary creatinine
concentration.
Results : In school children, the geometric means of the
urinary 1-OHP, 2-naphthol, hippuric acid and TBARS levels
were 0.02 Gmol/mol creatinine, 0.47 Gmol/mol creatinine,
0.14 g/g creatinine and 0.95 Gmol/g creatinine, respectively.
Those values for the elderly were 0.07 Gmol/mol creatinine,
1.87 Gmol/mol creatinine, 0.11 g/g creatinine and 1.18 G
mol/g creatinine, respectively. The mean levels of urinary 1-
OHP, 2-naphthol and TBARS were significantly higher in
the elderly subjects than in the children. The urinary
TBARS level was not correlated with the urinary 1-OHP, 2-
naphthol and hippuric acid, but they were correlated with
the age of the subjects.
Conclusions : These results suggest that low level
inhalation exposure to PAH or toluene does not markedly
increase lipid peroxidation, and age is a significant
determinant of lipid peroxidation.

영어초록

Objectives : Polycyclic aromatic hydrocarbons (PAH) and
toluene have been reported to induce reactive oxygen
species and oxidative stress. This study was performed to
investigate the effects of low level exposure to PAHs or
toluene on the lipid peroxidation level in elementary school
children and the elderly in a rural area.
Methods : Forty seven elementary school children and 40
elderly people who were living in a rural area and not
occupationally exposed to PAH or toluene were the
subjects of this study. Information about active or passive
smoking and diet was obtained using a self-administered
questionnaire. The urinary 1-hydroxypyrene (1-OHP), 2-
naphthol, hippuric acid and thiobarbituric acid reactive
substance (TBARS) concentrations were measured, and
these values were corrected with the urinary creatinine
concentration.
Results : In school children, the geometric means of the
urinary 1-OHP, 2-naphthol, hippuric acid and TBARS levels
were 0.02 Gmol/mol creatinine, 0.47 Gmol/mol creatinine,
0.14 g/g creatinine and 0.95 Gmol/g creatinine, respectively.
Those values for the elderly were 0.07 Gmol/mol creatinine,
1.87 Gmol/mol creatinine, 0.11 g/g creatinine and 1.18 G
mol/g creatinine, respectively. The mean levels of urinary 1-
OHP, 2-naphthol and TBARS were significantly higher in
the elderly subjects than in the children. The urinary
TBARS level was not correlated with the urinary 1-OHP, 2-
naphthol and hippuric acid, but they were correlated with
the age of the subjects.
Conclusions : These results suggest that low level
inhalation exposure to PAH or toluene does not markedly
increase lipid peroxidation, and age is a significant
determinant of lipid peroxidation.

참고자료

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