순차적 복합 림프종 2예 (Two Cases of Sequential Composite Lymphoma)

서지정보

· 발행기관 : 대한피부과학회
· 수록지 정보 : 대한피부과학회지 / 47권 / 8호 / 918 ~ 924페이지
· 저자명 : 최민지, 김정은, 오신택, 조백기, 박현정

초록

It is uncommon that two phenotypically different lymphomas develop in the same person, and especially in the skin.
Composite lymphoma is defined as two distinctly demarcated types of non-Hodgkin’s lymphoma (NHL) or its
association with Hodgkin’s lymphoma (HL) within a single organ or tissue. Discordant lymphoma is defined as two
types of NHL or the association of HL with NHL at different anatomic sites in the same person. Sequential
lymphoma and simultaneous lymphoma are defined as two different types of lymphoma that occur in the same
person at different times and at the same times, respectively. We herein report on two cases of sequential composite
lymphomas that were limited to the skin. A 57-year-old woman who had had been diagnosed with HL at the face
had been treated with chemotherapy for 1.5 years. 6 months later, the patient revisited the dermatologic clinic of our
hospital for a one-month history of erythematous nodules on her chest and upper extremities. Punch biopsy was
performed and the pathologic diagnosis was mantle cell lymphoma. She refused further treatment. A 68-year old
woman, who had been diagnosed as having extranodal marginal zone B cell lymphoma, had been treated with
chemotherapy and radiation therapy for one year. After one year, she revisited dermatologic clinic of our hospital
for a several-month history of erythematous nodules on her extremities. Punch biopsy from the lesion was performed
and the pathologic diagnosis was cutaneous diffuse large B cell lymphoma, the leg type. She was scheduled for
chemotherapy (rituximab with cyclophosphamide, adriamycin, vincristine and prednisolone (R-CHOP)). To the best
of our knowledge, our cases are the first such cases in the Korean dermatologic literature.

영어초록

It is uncommon that two phenotypically different lymphomas develop in the same person, and especially in the skin.
Composite lymphoma is defined as two distinctly demarcated types of non-Hodgkin’s lymphoma (NHL) or its
association with Hodgkin’s lymphoma (HL) within a single organ or tissue. Discordant lymphoma is defined as two
types of NHL or the association of HL with NHL at different anatomic sites in the same person. Sequential
lymphoma and simultaneous lymphoma are defined as two different types of lymphoma that occur in the same
person at different times and at the same times, respectively. We herein report on two cases of sequential composite
lymphomas that were limited to the skin. A 57-year-old woman who had had been diagnosed with HL at the face
had been treated with chemotherapy for 1.5 years. 6 months later, the patient revisited the dermatologic clinic of our
hospital for a one-month history of erythematous nodules on her chest and upper extremities. Punch biopsy was
performed and the pathologic diagnosis was mantle cell lymphoma. She refused further treatment. A 68-year old
woman, who had been diagnosed as having extranodal marginal zone B cell lymphoma, had been treated with
chemotherapy and radiation therapy for one year. After one year, she revisited dermatologic clinic of our hospital
for a several-month history of erythematous nodules on her extremities. Punch biopsy from the lesion was performed
and the pathologic diagnosis was cutaneous diffuse large B cell lymphoma, the leg type. She was scheduled for
chemotherapy (rituximab with cyclophosphamide, adriamycin, vincristine and prednisolone (R-CHOP)). To the best
of our knowledge, our cases are the first such cases in the Korean dermatologic literature.

참고자료

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