제 2형 콜라겐 유도 관절염에서 수중운동과 우슬추출물이 행동반응과 관절 조직에 미치는 영향 (The Effect of Behavioral Response and Arthritic Tissue on Swimming Exercise and Achyranthes Radix Extracts in Type Ⅱ Collagen-Induced Arthritic Rat)

서지정보

· 발행기관 : 대한물리치료학회
· 수록지 정보 : 대한물리치료학회지 / 21권 / 2호 / 117 ~ 124페이지
· 저자명 : 최기복, 김계엽, 남기원, 김경윤, 김은정

초록

Purpose: This study examined the effects of swimming exercise and Achyranthes Radix extracts on the inflammatory
and behavioral responses in type Ⅱ collagen‐induced arthritic rats for 28 days.
Methods: Sprague‐Dawley rats were allocated randomly to one of the following four groups: only type Ⅱ collageninduced
(group Ⅰ), application of swimming exercise after type Ⅱ collagen‐induced (group Ⅱ), application of Achyranthes
Radix ointment after type Ⅱ collagen‐induced (group Ⅲ), application of swimming exercise and Achyranthes Radix
ointment after type Ⅱ collagen‐induced (group Ⅳ). Arthritis was established in SD rats by an intradermal injection of
Chick type Ⅱcollagen plus incomplete Freund's adjuvant at the base of the tail of the animals. The swimming exercise
program consisted of a 25 min swimming session/day with a load corresponding to 5.5% of the weight bearing, three
days/week for four weeks. The Achyranthes Radix ointment (0.1g) was applied twice a day for five days. The changes
in behavior, H & E stain, and cyclooxygenase‐2 (COX‐2) level in the knee joint were assessed.
Results: The gross and histological examination, after RA induction showed reddening, edema and erythema. The H &
E stain revealed the destruction of articular cartilage, bony erosion and the infiltration of inflammatory cells after RA
induction. The mechanical allodynia test results were significantly higher in group Ⅰ than in groups Ⅱ, Ⅲ and Ⅳ (p<0.01).
The immunohistochemistrical response of COX‐2 in the knee joint showed that groups Ⅱ, Ⅲ, Ⅳ had a lower response
effect than groupⅠ.
Conclusion: Swimming exercise training and Achyranthes Radix ointment decreased the inflammatory responses and
enhanced the behavioral responses in the arthritic rats.

영어초록

Purpose: This study examined the effects of swimming exercise and Achyranthes Radix extracts on the inflammatory
and behavioral responses in type Ⅱ collagen‐induced arthritic rats for 28 days.
Methods: Sprague‐Dawley rats were allocated randomly to one of the following four groups: only type Ⅱ collageninduced
(group Ⅰ), application of swimming exercise after type Ⅱ collagen‐induced (group Ⅱ), application of Achyranthes
Radix ointment after type Ⅱ collagen‐induced (group Ⅲ), application of swimming exercise and Achyranthes Radix
ointment after type Ⅱ collagen‐induced (group Ⅳ). Arthritis was established in SD rats by an intradermal injection of
Chick type Ⅱcollagen plus incomplete Freund's adjuvant at the base of the tail of the animals. The swimming exercise
program consisted of a 25 min swimming session/day with a load corresponding to 5.5% of the weight bearing, three
days/week for four weeks. The Achyranthes Radix ointment (0.1g) was applied twice a day for five days. The changes
in behavior, H & E stain, and cyclooxygenase‐2 (COX‐2) level in the knee joint were assessed.
Results: The gross and histological examination, after RA induction showed reddening, edema and erythema. The H &
E stain revealed the destruction of articular cartilage, bony erosion and the infiltration of inflammatory cells after RA
induction. The mechanical allodynia test results were significantly higher in group Ⅰ than in groups Ⅱ, Ⅲ and Ⅳ (p<0.01).
The immunohistochemistrical response of COX‐2 in the knee joint showed that groups Ⅱ, Ⅲ, Ⅳ had a lower response
effect than groupⅠ.
Conclusion: Swimming exercise training and Achyranthes Radix ointment decreased the inflammatory responses and
enhanced the behavioral responses in the arthritic rats.

참고자료

· 없음