만성 비부비동염 점막에서 정적 및 동적 섬모운동 양상의 변화 및 임상 양상과의 관련성 (Ciliary Activity in Basal and Activated Status and Its Correlation with Clinical Findings in Chronic Rhinosinusitis)

서지정보

· 발행기관 : 대한이비인후과학회
· 수록지 정보 : 대한이비인후-두경부외과학회지 / 51권 / 2호 / 136 ~ 140페이지
· 저자명 : 김인상, 김혜영, 배승현, 강정욱, 이재서

초록

There are conflicting results about ciliary activity in chronic rhinosinusitis (CRS). And dynamic
movements reacting to various stimuli in sinusitis mucosa have been studied rarely. This study was designed to investigate the
ciliary activity according to the severity of sinusitis and clinical symptoms. We aimed to identify the dynamic ciliary activity in
response to purinergic stimulation in sinusitis. Subjects and Method：Nasal mucosal samples were obtained from 44 CRS and
20 normal subjects. We measured ciliary beat frequency (CBF) in the basal and activated status. For evaluating the correlation
of CBF with clinical findings, nasal symptoms, endoscopic findings, CT findings, allergy tests, and olfactory tests were reviewed.
Results：No significant differences were found in basal CBF between normal and CRS mucosa. However, the CBF stimulated
by ATP in normal and CRS mucosa showed marked differences：both the maximal increase and duration of increased CBF by
ATP were significantly reduced in CRS mucosa. The olfactory test showed significant correlation with basal CBF, but the presence
of allergy or nasal symptoms did not show significant correlation with the basal CBF. The CT score and presence of nasal polyposis
showed negative correlation with the basal CBF (p<0.05). Conclusion：The basal CBF of normal and CRS mucosa
showed no difference. However, dynamic ciliary activity responding to purinergic stimulation was markedly attenuated in sinusitis
mucosa. The severity of sinusitis and presence of polyposis negatively affected CBF. (Korean J Otorhinolaryngol-Head Neck
Surg 2008;51:136-40)

영어초록

There are conflicting results about ciliary activity in chronic rhinosinusitis (CRS). And dynamic
movements reacting to various stimuli in sinusitis mucosa have been studied rarely. This study was designed to investigate the
ciliary activity according to the severity of sinusitis and clinical symptoms. We aimed to identify the dynamic ciliary activity in
response to purinergic stimulation in sinusitis. Subjects and Method：Nasal mucosal samples were obtained from 44 CRS and
20 normal subjects. We measured ciliary beat frequency (CBF) in the basal and activated status. For evaluating the correlation
of CBF with clinical findings, nasal symptoms, endoscopic findings, CT findings, allergy tests, and olfactory tests were reviewed.
Results：No significant differences were found in basal CBF between normal and CRS mucosa. However, the CBF stimulated
by ATP in normal and CRS mucosa showed marked differences：both the maximal increase and duration of increased CBF by
ATP were significantly reduced in CRS mucosa. The olfactory test showed significant correlation with basal CBF, but the presence
of allergy or nasal symptoms did not show significant correlation with the basal CBF. The CT score and presence of nasal polyposis
showed negative correlation with the basal CBF (p<0.05). Conclusion：The basal CBF of normal and CRS mucosa
showed no difference. However, dynamic ciliary activity responding to purinergic stimulation was markedly attenuated in sinusitis
mucosa. The severity of sinusitis and presence of polyposis negatively affected CBF. (Korean J Otorhinolaryngol-Head Neck
Surg 2008;51:136-40)

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