2세 이하 아토피 피부염 환아에서 모유수유가 식품알레르기 증상과 식품항원 감작에 미치는 영향 (Breastfeeding increases the risk of food sensitization but not aff ect food allergy symptoms in young children with atopic dermatitis)

서지정보

· 발행기관 : 대한 소아알레르기 호흡기학회
· 수록지 정보 : Allergy Asthma & Respiratory Disease / 4권 / 3호 / 188 ~ 194페이지
· 저자명 : 김동찬, 서안덕, 양송이, 이혜란, 이소연

초록

Purpose: Breast-feeding is recommended to prevent allergies, particularly in high-risk infants, but the evidence of protective eff ects that breast-feeding has on food allergy (FA) remains elusive. The aim of this study was to investigate risk factors of FA and the associ- ation between breast-feeding and FA symptoms/food sensitization (FS) in children with atopic dermatitis under 2 years of age.
Methods: We reviewed the medical records of 384 children with atopic dermatitis under 2 years of age who visited our pediatric al- lergy clinic from March 1, 2009 through December 31, 2014. Symptoms of FA, feeding type, and family history of allergic disease were assessed. Laboratory tests were conducted, including serum total IgE, eosinophil (%), serum 25-hydroxyvitamin D, and specifi c IgE to egg white, milk, soy, peanut, and wheat.
Results: Subjects were divided into 3 groups based on FA symptoms and evidence of sensitization: The FA symptom group (n=240), no symptom group (n=53) and no FS group (n=91). The FA symptom group had a higher log total IgE level (2.0 vs. 1.3, P<0.001) and eosinophil (%) (7.0% vs. 4.7%, P=0.001) than the no FA symptom group. In multivariate analysis, breast-feeding was associated with FS (adjusted odds ratio [aOR], 2.43; 95% confi dence intervals [CI], 1.03–5.74) but was not associated with FA symptoms (aOR, 0.65; 95% CI, 0.23–1.83).
Conclusion: Breast-feeding may increase the risk of FS, but not immediate-type FA symptoms in children with atopic dermatitis.

영어초록

Purpose: Breast-feeding is recommended to prevent allergies, particularly in high-risk infants, but the evidence of protective eff ects that breast-feeding has on food allergy (FA) remains elusive. The aim of this study was to investigate risk factors of FA and the associ- ation between breast-feeding and FA symptoms/food sensitization (FS) in children with atopic dermatitis under 2 years of age.
Methods: We reviewed the medical records of 384 children with atopic dermatitis under 2 years of age who visited our pediatric al- lergy clinic from March 1, 2009 through December 31, 2014. Symptoms of FA, feeding type, and family history of allergic disease were assessed. Laboratory tests were conducted, including serum total IgE, eosinophil (%), serum 25-hydroxyvitamin D, and specifi c IgE to egg white, milk, soy, peanut, and wheat.
Results: Subjects were divided into 3 groups based on FA symptoms and evidence of sensitization: The FA symptom group (n=240), no symptom group (n=53) and no FS group (n=91). The FA symptom group had a higher log total IgE level (2.0 vs. 1.3, P<0.001) and eosinophil (%) (7.0% vs. 4.7%, P=0.001) than the no FA symptom group. In multivariate analysis, breast-feeding was associated with FS (adjusted odds ratio [aOR], 2.43; 95% confi dence intervals [CI], 1.03–5.74) but was not associated with FA symptoms (aOR, 0.65; 95% CI, 0.23–1.83).
Conclusion: Breast-feeding may increase the risk of FS, but not immediate-type FA symptoms in children with atopic dermatitis.

참고자료

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