아토피피부염 환자에서 바퀴벌레 항원의 기제 및 농도에 따른 아토피 첩포검사 (Atopy Patch Tests for Atopic Dermatitis Patients according to the Concentration and Vehicle for the Cockroach Antigen)

서지정보

· 발행기관 : 대한피부과학회
· 수록지 정보 : 대한피부과학회지 / 47권 / 4호 / 425 ~ 430페이지
· 저자명 : 김혜원, 한희진, 이희봉, 최지훈, 박천욱, 이철헌

초록

Background: Recent studies have attempted to document the correlation of an atopy patch test (APT) and a skin
prick test. The results have suggested a possible role of delayed allergic reaction in the development of eczematous
skin lesions in patients with atopic dermatitis (AD).
Objective: The aim of this study was to evaluate the relationship of APT with skin prick test and specific IgE for
cockroach antigen. And we attempted to find the optimal vehicle and concentration of APT for cockroach allergy
in AD patient.
Methods: We performed APTs in 50 patients with AD with using German cockroach allergens (the extract with
different concentrations and vehicles). The reactions were evaluated after 48 hours, and these were compared with
the results of the skin prick test and the total and specific IgE levels.
Results: The AD patients who had cockroach allergy, according to a skin prick test or the specific IgE level,
showed higher positive APT reactionsthan the non-allergic patients to cockroach. The APT reactions showed a
significant relationship with the skin prick test and the specific IgE level (85.7%). With regard to the form of
cockroach antigen, a positive APT was more frequent with using the powder form that with using the extract.
Regarding the vehicle, petrolatum induced higher positive APT reactions than did distilled water. There was a close
relationship between the antigen concentration in petrolatum base and a positive APT reaction. Ten and fifty percent
cockroach antigen elicited positive APT reactions than did 1% cockroach antigen with using a petrolatum base.
Conclusion: Petrolatum is an optimal vehicle for an APT for cockroach because an APT with a petrolatum base
revealed the highest correlation with cockroach allergy. The dose-response relationship between antigen concentration
and the frequencies of positive APT reactions demonstrated that 10% and 50% cockroach antigen is superior to 1%
cockroach antigen.

영어초록

Background: Recent studies have attempted to document the correlation of an atopy patch test (APT) and a skin
prick test. The results have suggested a possible role of delayed allergic reaction in the development of eczematous
skin lesions in patients with atopic dermatitis (AD).
Objective: The aim of this study was to evaluate the relationship of APT with skin prick test and specific IgE for
cockroach antigen. And we attempted to find the optimal vehicle and concentration of APT for cockroach allergy
in AD patient.
Methods: We performed APTs in 50 patients with AD with using German cockroach allergens (the extract with
different concentrations and vehicles). The reactions were evaluated after 48 hours, and these were compared with
the results of the skin prick test and the total and specific IgE levels.
Results: The AD patients who had cockroach allergy, according to a skin prick test or the specific IgE level,
showed higher positive APT reactionsthan the non-allergic patients to cockroach. The APT reactions showed a
significant relationship with the skin prick test and the specific IgE level (85.7%). With regard to the form of
cockroach antigen, a positive APT was more frequent with using the powder form that with using the extract.
Regarding the vehicle, petrolatum induced higher positive APT reactions than did distilled water. There was a close
relationship between the antigen concentration in petrolatum base and a positive APT reaction. Ten and fifty percent
cockroach antigen elicited positive APT reactions than did 1% cockroach antigen with using a petrolatum base.
Conclusion: Petrolatum is an optimal vehicle for an APT for cockroach because an APT with a petrolatum base
revealed the highest correlation with cockroach allergy. The dose-response relationship between antigen concentration
and the frequencies of positive APT reactions demonstrated that 10% and 50% cockroach antigen is superior to 1%
cockroach antigen.

참고자료

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