일과성 Immunoglobulin G 결핍증이 있는 아토피피부염 환아에서 면역글로불린 치료 (Intravenous Immunoglobulin Treatment to Severe Atopic Dermatitis with Transient Immunoglobulin G Deficiency)

서지정보

· 발행기관 : 대한천식알레르기학회
· 수록지 정보 : 천식 및 알레르기 / 32권 / 3호 / 190 ~ 192페이지
· 저자명 : 백종욱, 이혜란, 이소연

초록

Background: Some studies have reported that intravenous immunoglobulin is an effective treatment of severe atopic dermatitis.
Case History: A 3-month-old by present suffered from atopic dermatitis with skin infection since the age of 50days. He was fed on breast milk and had no familial history of allergy. Upon admission, his body weight was 6.9 kg (50percentile), and the Severity Scoring of Atopic Dermatitis was 80. Laboratory test results were as follows: white blood cell 23.1×103/uL, eosinophil (%) 29%, immunoglobulin E 696.2 IU/mL, immunoglobulin G 126 mg/dL (176∼601mg/dL), immunoglobulin A 14.7 mg/dL (1.3∼53 mg/dL),immunoglobulin M 31.7 mg/dL (17∼105 mg/dL). Staphylococcus aureus was detected in the erosive cheek by skin cultures. Specific immunoglobulin E levels to egg white,soy, and peanut were elevated. He was initially treated with intravenous antibiotics, wet dressing, steroid ointments, and mother’s dietary restriction. However, the skin infection and atopic dermatitis remained uncontrolled, and the immunoglobulin G level was still below the normal range. The patient was given intravenous immunoglobulin 1 g/kg/day for 2consecutive days.
Results: After 4 days, the skin infection was controlled.
After 9 months, immunoglobulin G level was normalized.
Conclusion: We reported a patient who was diagnosed with severe atopic dermatitis with transient immunoglobulin G deficiency and whose symptoms improved after intravenous administration of immunoglobulin.

영어초록

Background: Some studies have reported that intravenous immunoglobulin is an effective treatment of severe atopic dermatitis.
Case History: A 3-month-old by present suffered from atopic dermatitis with skin infection since the age of 50days. He was fed on breast milk and had no familial history of allergy. Upon admission, his body weight was 6.9 kg (50percentile), and the Severity Scoring of Atopic Dermatitis was 80. Laboratory test results were as follows: white blood cell 23.1×103/uL, eosinophil (%) 29%, immunoglobulin E 696.2 IU/mL, immunoglobulin G 126 mg/dL (176∼601mg/dL), immunoglobulin A 14.7 mg/dL (1.3∼53 mg/dL),immunoglobulin M 31.7 mg/dL (17∼105 mg/dL). Staphylococcus aureus was detected in the erosive cheek by skin cultures. Specific immunoglobulin E levels to egg white,soy, and peanut were elevated. He was initially treated with intravenous antibiotics, wet dressing, steroid ointments, and mother’s dietary restriction. However, the skin infection and atopic dermatitis remained uncontrolled, and the immunoglobulin G level was still below the normal range. The patient was given intravenous immunoglobulin 1 g/kg/day for 2consecutive days.
Results: After 4 days, the skin infection was controlled.
After 9 months, immunoglobulin G level was normalized.
Conclusion: We reported a patient who was diagnosed with severe atopic dermatitis with transient immunoglobulin G deficiency and whose symptoms improved after intravenous administration of immunoglobulin.

참고자료

· 없음