고려홍삼의 콜라겐 유도 관절염의 예방과 억제효과 (Preventive and Inhibitory Effect of Korean Red Ginseng on Collagen-Induced Arthritis in Mice)

서지정보

· 발행기관 : 고려인삼학회
· 수록지 정보 : Journal of Ginseng Research / 33권 / 2호 / 149 ~ 154페이지
· 저자명 : 조미란, 왕옥철, 장진선, 김채균

초록

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and progressive
cartilage and bone erosion. Korean red ginseng (KRG) has been shown to have an anti-inflammatory effect by
inhibiting the secretion of inflammatory cytokines like TNF-α, IL-1, -6, and -8, and IFN-γ. In this study, whether KRG
extract has an inhibitory effect on the collagen-inducible development of arthritis in DBA/1J mice was investigated. To
induce arthritis, type II collagen emulsified in Complete Freund’s Adjuvant was intradermally injected into the base of the
tails of mice. Three weeks after the initial injection, a booster injection of type II collagen emulsified in Incomplete Freund’s
Adjuvant was administered. The oral administration of KRG extract for 8~10 weeks at the dose of 300 mg/kg (three
days a week) inhibited the development of arthritis in the experimental group, compared to the control group which was
given saline. While the administration of KRG extract three times a week demonstrated both preventive and inhibitory
effects, the administration of KRG extract once a week had little inhibitory effect. In other studies, the regimen of KRG
administration has been shown to decrease the plasma level of inflammatory cytokines like IL-8 and TNF-α, but the
plasma levels of these cytokines were not decreased in the present study. The results of the present study suggest that
KRG has preventive and inhibitory effects on collagen-induced arthritis.

영어초록

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and progressive
cartilage and bone erosion. Korean red ginseng (KRG) has been shown to have an anti-inflammatory effect by
inhibiting the secretion of inflammatory cytokines like TNF-α, IL-1, -6, and -8, and IFN-γ. In this study, whether KRG
extract has an inhibitory effect on the collagen-inducible development of arthritis in DBA/1J mice was investigated. To
induce arthritis, type II collagen emulsified in Complete Freund’s Adjuvant was intradermally injected into the base of the
tails of mice. Three weeks after the initial injection, a booster injection of type II collagen emulsified in Incomplete Freund’s
Adjuvant was administered. The oral administration of KRG extract for 8~10 weeks at the dose of 300 mg/kg (three
days a week) inhibited the development of arthritis in the experimental group, compared to the control group which was
given saline. While the administration of KRG extract three times a week demonstrated both preventive and inhibitory
effects, the administration of KRG extract once a week had little inhibitory effect. In other studies, the regimen of KRG
administration has been shown to decrease the plasma level of inflammatory cytokines like IL-8 and TNF-α, but the
plasma levels of these cytokines were not decreased in the present study. The results of the present study suggest that
KRG has preventive and inhibitory effects on collagen-induced arthritis.

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