역류식도염 환자에서 Helicobacter pylori 감염과 Gastrin, Pepsinogen의 관계 - 역류식도염과 H. pylori 감염, 위축위염의 관계 (The Relationship of Gastrin, Pepsinogen, and Helicobacter pylori in Erosive Reflux Esophagitis)

서지정보

· 발행기관 : 대한소화기학회
· 수록지 정보 : 대한소화기학회지 / 51권 / 3호 / 159 ~ 166페이지
· 저자명 : 권정현, 정인식, 손혜숙, 박재명, 조유경, 이인석, 김상우, 최명규

초록

Background/Aims: Helicobacter pylori (H. pylori) infection is known as a major cause of atrophic gastritis and is associated with serum gastrin, pepsinogen, and gastric acid secretion. There is still a controversial association between gastroesophageal reflux disease and H. pylori infection. This study was designed to investigate the relationship among serum gastrin, pepsinogen, and H. pylori infection in the erosive reflux esophagitis (ERD) patients. Methods: Patients who were diagnosed as ERD by one gastroenterologist at the Kangnam St. Mary’s hospital were prospectively enrolled. The persons without ERD in the control group were matched for age and sex. We examined the gastrin, pepsinogen I (PG I), PG II, PG I/II ratio, and H. pylori infection. Results: Forty five patients were enrolled in ERD group and 66 persons in control group. The H. pylori infection rate in ERD group was lower than that in the control group (11.1% vs. 43.9%, p＜0.001). PG I/II ratio in ERD group was higher than that in the control group (7.0±3.1 vs. 5.3±2.6, p=0.003). The PG II (p=0.016) and gastrin (p=0.029) in ERD group were lower than those in the control group. BMI in ERD group was higher than that in the control group (24.5 vs. 23.1 kg/m2, p=0.013). Conclusions: The H. pylori infection rate in ERD group was lower and PG I/II ratio was higher than that in the control group. Reflux esophagitis is thought to be reversely associated with the atrophy of gastric mucosa. (Korean J Gastroenterol 2008;51:159-166)

영어초록

Background/Aims: Helicobacter pylori (H. pylori) infection is known as a major cause of atrophic gastritis and is associated with serum gastrin, pepsinogen, and gastric acid secretion. There is still a controversial association between gastroesophageal reflux disease and H. pylori infection. This study was designed to investigate the relationship among serum gastrin, pepsinogen, and H. pylori infection in the erosive reflux esophagitis (ERD) patients. Methods: Patients who were diagnosed as ERD by one gastroenterologist at the Kangnam St. Mary’s hospital were prospectively enrolled. The persons without ERD in the control group were matched for age and sex. We examined the gastrin, pepsinogen I (PG I), PG II, PG I/II ratio, and H. pylori infection. Results: Forty five patients were enrolled in ERD group and 66 persons in control group. The H. pylori infection rate in ERD group was lower than that in the control group (11.1% vs. 43.9%, p＜0.001). PG I/II ratio in ERD group was higher than that in the control group (7.0±3.1 vs. 5.3±2.6, p=0.003). The PG II (p=0.016) and gastrin (p=0.029) in ERD group were lower than those in the control group. BMI in ERD group was higher than that in the control group (24.5 vs. 23.1 kg/m2, p=0.013). Conclusions: The H. pylori infection rate in ERD group was lower and PG I/II ratio was higher than that in the control group. Reflux esophagitis is thought to be reversely associated with the atrophy of gastric mucosa. (Korean J Gastroenterol 2008;51:159-166)

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