대사증후군에서 중심대동맥압의 변화 (The Changes of Central Aortic Pulse Wave Analysis in Metabolic Syndrome)

서지정보

· 발행기관 : 대한당뇨병학회
· 수록지 정보 : Diabetes and Metabolism Journal / 32권 / 6호 / 522 ~ 528페이지
· 저자명 : 이지인, 손태서, 권혁상, 이정민, 장상아, 차봉연, 손현식

초록

The metabolic syndrome (MS) has been characterized as a cluster of risk factors that includes dyslipidemia,
hypertension, glucose intolerance and central obesity. This syndrome increases the risk of cardiovascular
disease. Augmentation index (AIx), a composite of wave reflection form medium-sized muscular arteries is
related to the development of coronary artery disease. The aim of this study is to examine the change on
central aortic waveforms in subjects between patients with metabolic syndrome and normal subjects. Using
the non-invasive technique of pulse wave analysis by applantation tonometry, we investigated central aortic
waveforms in 45 patients with MS and 45 matched controls. The MS was defined by NCEP-ATP III criteria.
Age did not differ between the two groups. AIx was significantly elevated in patinets with MS compared
with controls (21.91 ± 11.41% vs 18.14 ± 11.07%; P < 0.01). Subendocardial viability ratio (SEVR) (158.09 ±
28.69 vs 167.09 ± 30.06; P < 0.01) was significantly decreased in patients with MS compared with controls.
Only the fasting glucose (r = 0.317, P = 0.03) among the components of MS and age (r = 0.424, P = 0.004)
had a positive correlation with AIx. AIx increased as the number of MS components increased. These results
show that the MS increased systemic arterial stiffness. Age and fasting blood glucose are independent risk
factors of arterial stiffness in MS. The individual MS components, except for fasting blood glucose, do not
affect arterial stiffness independently. But the clustering of MS components might interact to synergistically
affect arterial stiffness. (KOREAN DIABETES J 32:522-528, 2008)

영어초록

The metabolic syndrome (MS) has been characterized as a cluster of risk factors that includes dyslipidemia,
hypertension, glucose intolerance and central obesity. This syndrome increases the risk of cardiovascular
disease. Augmentation index (AIx), a composite of wave reflection form medium-sized muscular arteries is
related to the development of coronary artery disease. The aim of this study is to examine the change on
central aortic waveforms in subjects between patients with metabolic syndrome and normal subjects. Using
the non-invasive technique of pulse wave analysis by applantation tonometry, we investigated central aortic
waveforms in 45 patients with MS and 45 matched controls. The MS was defined by NCEP-ATP III criteria.
Age did not differ between the two groups. AIx was significantly elevated in patinets with MS compared
with controls (21.91 ± 11.41% vs 18.14 ± 11.07%; P < 0.01). Subendocardial viability ratio (SEVR) (158.09 ±
28.69 vs 167.09 ± 30.06; P < 0.01) was significantly decreased in patients with MS compared with controls.
Only the fasting glucose (r = 0.317, P = 0.03) among the components of MS and age (r = 0.424, P = 0.004)
had a positive correlation with AIx. AIx increased as the number of MS components increased. These results
show that the MS increased systemic arterial stiffness. Age and fasting blood glucose are independent risk
factors of arterial stiffness in MS. The individual MS components, except for fasting blood glucose, do not
affect arterial stiffness independently. But the clustering of MS components might interact to synergistically
affect arterial stiffness. (KOREAN DIABETES J 32:522-528, 2008)

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