대장암의 근치적 절제를 시행한 환자에 있어서 ErbB1 (EGFR) 발현의 예후 인자적 중요성 (The Prognostic Significance of ErbB1 (EGFR) Expressions in Patients with Curative Resection for Colorectal Cancers)

서지정보

· 발행기관 : 대한대장항문학회
· 수록지 정보 : Annals of Coloproctolgy / 24권 / 6호 / 453 ~ 459페이지
· 저자명 : 강상희, 김성수, 민병욱, 이주한, 엄준원

초록

Purpose: The ErbB family is associated with cell growth,
differentiation, cell survival, apoptosis, cell cycle progression,
angiogenesis. In this study, the expressions of
ErbB family of colorectal cancer specimen were investigated
to determined correlations between the clinicopathologic
characteristics and the expression of ErbB
family in the curative resection for colorectal cancers, including
cancer specific survival. Methods: Patients who
underwent the curative surgery for colorectal cancers
from January 1997 to December 2000 at Ansan Medical
Center, Korea University College of Medicine were enrolled
in this study, and one hundred ninety six of colorectal
cancer. The clinical relationship between the expression
of ErbB family for colon adenocarcinoma and
clinicopathologic characteristic factors including survival
were analyzed. Results: There was no clinical relationship
of the expression of ErbB family with clinicopatholologic
characteristics. However, survival analysis demonstrated
that 5 year survival rates (5YSR) of patients with the positive
expression of ErbB1 (EGFR) was lower than those
of the negative expression of ErbB1 (P＜0.05) in colorectal
cancer patients. Moreover 5YSR of the positive expression
of ErbB1 was lower than that of negative expression
of ErbB1 in well differentiation subgroup, node
negative subgroup, node positive subgroup, and also stage
T3 subgroup (P＜0.05). Conclusions: The positive ErbB1
expression of colorectal cancer was one of poor prognostic
factors in patients with colorectal cancer in this
study. We need the further study to prove the real relation
between target therapy for the positive expression
of ErbB1 (EGFR) in colorectal cancer and the improvement
of survival rate.

영어초록

Purpose: The ErbB family is associated with cell growth,
differentiation, cell survival, apoptosis, cell cycle progression,
angiogenesis. In this study, the expressions of
ErbB family of colorectal cancer specimen were investigated
to determined correlations between the clinicopathologic
characteristics and the expression of ErbB
family in the curative resection for colorectal cancers, including
cancer specific survival. Methods: Patients who
underwent the curative surgery for colorectal cancers
from January 1997 to December 2000 at Ansan Medical
Center, Korea University College of Medicine were enrolled
in this study, and one hundred ninety six of colorectal
cancer. The clinical relationship between the expression
of ErbB family for colon adenocarcinoma and
clinicopathologic characteristic factors including survival
were analyzed. Results: There was no clinical relationship
of the expression of ErbB family with clinicopatholologic
characteristics. However, survival analysis demonstrated
that 5 year survival rates (5YSR) of patients with the positive
expression of ErbB1 (EGFR) was lower than those
of the negative expression of ErbB1 (P＜0.05) in colorectal
cancer patients. Moreover 5YSR of the positive expression
of ErbB1 was lower than that of negative expression
of ErbB1 in well differentiation subgroup, node
negative subgroup, node positive subgroup, and also stage
T3 subgroup (P＜0.05). Conclusions: The positive ErbB1
expression of colorectal cancer was one of poor prognostic
factors in patients with colorectal cancer in this
study. We need the further study to prove the real relation
between target therapy for the positive expression
of ErbB1 (EGFR) in colorectal cancer and the improvement
of survival rate.

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