광선입술염과 편평세포암의 임상, 병리조직학적 관찰 및p53 단백 발현양상 (Actinic Cheilitis and Lip Squamous Cell Carcinoma: Clinical and, Histopathological Aspects and p53 Protein Expression)

서지정보

· 발행기관 : 대한피부과학회
· 수록지 정보 : 대한피부과학회지 / 52권 / 10호 / 701 ~ 710페이지
· 저자명 : 이용우, 윤숙정, 이지범, 김성진, 이승철, 원영호

초록

Background: Actinic cheilitis (AC) is the main precancerous lesion of the lip. Knowledge of prognostic anddiagnostic markers can have positive impacts, although the exact transition rate from AC to lip squamous cellcarcinoma (LSCC) is unknown.
Objective: We analyzed 59 patients to investigate the relationship between clinical and histopathological features andthe expression of the p53 protein in AC and LSCC.
Methods: We retrospectively reviewed 59 patients who received biopsy for AC and LSCC between January 2005and December 2012 and compared clinical and histopathological features of AC and LSCC.
Results: The ratios of males to females for AC and LSCC were 1.3:1 and 1.7:1. The mean ages of those with ACand LSCC were 66.4 and 70.1 years. All of the lesions involved the lower lip, and the most frequently affected sitewas the right side of the lip in LSCC. Persistent fissures with scales and exudative ulcers were noted 90.6% and43.7% of the AC cases, respectively. The intensity of the inflammatory infiltrate was significantly associated withthe degree of epithelial dysplasia. Most LSCCs (96.2%) were immunoreactive to the p53 protein. The intensities ofAC and LSCC p53 protein expression were 1.1 and 2.4. The degree of epithelial dysplasia was the onlyhistopathological finding significantly associated with p53 protein expression.
Conclusion: An intense inflammatory infiltrate in AC was predictive of a microinvasive SCC. Therefore, p53protein immunoreactivity may be an important indicator in lip carcinogenesis and the degree of epithelial dysplasia.

영어초록

Background: Actinic cheilitis (AC) is the main precancerous lesion of the lip. Knowledge of prognostic anddiagnostic markers can have positive impacts, although the exact transition rate from AC to lip squamous cellcarcinoma (LSCC) is unknown.
Objective: We analyzed 59 patients to investigate the relationship between clinical and histopathological features andthe expression of the p53 protein in AC and LSCC.
Methods: We retrospectively reviewed 59 patients who received biopsy for AC and LSCC between January 2005and December 2012 and compared clinical and histopathological features of AC and LSCC.
Results: The ratios of males to females for AC and LSCC were 1.3:1 and 1.7:1. The mean ages of those with ACand LSCC were 66.4 and 70.1 years. All of the lesions involved the lower lip, and the most frequently affected sitewas the right side of the lip in LSCC. Persistent fissures with scales and exudative ulcers were noted 90.6% and43.7% of the AC cases, respectively. The intensity of the inflammatory infiltrate was significantly associated withthe degree of epithelial dysplasia. Most LSCCs (96.2%) were immunoreactive to the p53 protein. The intensities ofAC and LSCC p53 protein expression were 1.1 and 2.4. The degree of epithelial dysplasia was the onlyhistopathological finding significantly associated with p53 protein expression.
Conclusion: An intense inflammatory infiltrate in AC was predictive of a microinvasive SCC. Therefore, p53protein immunoreactivity may be an important indicator in lip carcinogenesis and the degree of epithelial dysplasia.

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