갑상선 암 진단 중 발견된 이차성 항인지질항체 증후군 1예 (A Case of Secondary Antiphospholipid Antibody Syndrome with Thyroid Cancer)

서지정보

· 발행기관 : 대한류마티스학회
· 수록지 정보 : 대한류마티스학회지 / 18권 / 1호 / 46 ~ 49페이지
· 저자명 : 강승훈, 최성재, 이영호, 지종대, 송관규

초록

최근 항인지질항체 증후군 환자에 있어서 악성 종양과의연관성이 의심되는 증례들이 보고 되고 있다 (2, 5,6,15). 저자들은 갑상선 암을 진단하고 수술 전 검사 중에 발견된 항인지질항체 증후군 1예를 경험하였기에 이를 보고하는 바이다. 항인지질항체 증후군 환자에서 혈액암 및 고형암 등의 악성 종양의 발생 빈도가 높은 양상을 보이므로 적절한 암 스크리닝을 시행하는 것이 권장된다.

영어초록

Antiphospholipid antibody syndrome (APS) is defined as the presence of lupus anticoagulant antibody or anticardiolipin antibody with vascular thrombosis or pregnancy complications.
APS can be associated with autoimmune disease or infectious disease. APS has also been reported in conjunction with variety of solid and hematologic malignancies.
There were some reports on APS which were accompanied by hematologic malignancy, but there was no report with solid malignancy in Korea. We experienced one case of secondary APS, which was diagnosed during pre-operative evaluation of thyroid cancer. This patient had prolonged aPTT (activate partial thromboplastin time) and decreased coagulation factors which were regarded as hemophilia at first. Although the precise mechanism of the relationship between APS and cancer has not been proven thoroughly,APS can be accompanied by various malignancies. So proper screening and early detection of malignancies in APS patients are recommended.

참고자료

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