시스템 약리학적 분석에 의한 절패모의 유방암 억제 작용 (Inhibitory Action of Fritillariae Thunbergii Bulbus on Breast Cancer by Systemic Pharmacological Analysis)

서지정보

· 발행기관 : 한약정보연구회
· 수록지 정보 : 한약정보연구회지(韓藥情報硏究會誌) / 8권 / 2호 / 167 ~ 182페이지
· 저자명 : 김병준, 김선중, 윤정민, 김윤숙, 이부균, 안원근

초록

Fritillariae Thunbergii Bulbus (FTB) contains alkaloids such as peimisine and peimine, and has traditionally been used to regulate airway inflammation and for antitussive and expectorant applications. According to a recent study, FTB extract has anti-H1N1 virus and anti-oxidant effect and suppresses breast cancer. Despite such diverse efficacy, there is still insufficient research on the specific mechanism of action of the FTB active ingredient for specific diseases. In this study, we confirmed the mechanism of breast cancer suppression of FTB main active ingredient through system pharmacological analysis. We secured 17 potential active compounds of FTB through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database and Analysis Platform and screened six active compounds that match the set ADME-related pharmacokinetic parameters. We have identified the information of 62 genes reacting to compounds through the UniProt database and secured 86 biological processes related to the collected genes with David 6.8 Gene Functional Classification Tool. We confirmed multiple interactions of compound-target and process-target through network construction. According to the results of pathway network analysis, FTB targeting genes, BAX, ESR1, ESR2, GSK3B, JUN, NCOA1, and PGR were found in the breast cancer signaling pathway and were involved in the regulation of cancer cell growth in the pathway. Network-level analysis, including the TCMSP database, which describes the pharmacokinetic profile of active ingredients and drug-target-disease associations, enables a breakthrough in silico access to therapeutic candidates. This not only adds accuracy to the selection of research materials but also saves time and money. The secured data will lead to experimental evidence for the effects of FTB extract and each active ingredient and will be presented as a scientific basis for future breast cancer prevention and treatment strategies.

영어초록

Fritillariae Thunbergii Bulbus (FTB) contains alkaloids such as peimisine and peimine, and has traditionally been used to regulate airway inflammation and for antitussive and expectorant applications. According to a recent study, FTB extract has anti-H1N1 virus and anti-oxidant effect and suppresses breast cancer. Despite such diverse efficacy, there is still insufficient research on the specific mechanism of action of the FTB active ingredient for specific diseases. In this study, we confirmed the mechanism of breast cancer suppression of FTB main active ingredient through system pharmacological analysis. We secured 17 potential active compounds of FTB through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database and Analysis Platform and screened six active compounds that match the set ADME-related pharmacokinetic parameters. We have identified the information of 62 genes reacting to compounds through the UniProt database and secured 86 biological processes related to the collected genes with David 6.8 Gene Functional Classification Tool. We confirmed multiple interactions of compound-target and process-target through network construction. According to the results of pathway network analysis, FTB targeting genes, BAX, ESR1, ESR2, GSK3B, JUN, NCOA1, and PGR were found in the breast cancer signaling pathway and were involved in the regulation of cancer cell growth in the pathway. Network-level analysis, including the TCMSP database, which describes the pharmacokinetic profile of active ingredients and drug-target-disease associations, enables a breakthrough in silico access to therapeutic candidates. This not only adds accuracy to the selection of research materials but also saves time and money. The secured data will lead to experimental evidence for the effects of FTB extract and each active ingredient and will be presented as a scientific basis for future breast cancer prevention and treatment strategies.

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