췌장암 수술환자에서 절제군과 비절제군의 생존율 비교 (Survival Rate of Pancreatic Cancer in Resected Group Versus Unresected Group)

서지정보

· 발행기관 : 고신대학교(의대) 고신대학교 의과대학 학술지
· 수록지 정보 : 고신대학교 의과대학 학술지 / 23권 / 1호 / 31 ~ 36페이지
· 저자명 : 윤명희

초록

Background : Pancreatic cancer is a common and highly fatal malignancy. Long-term survival is rare with only 5 % of patients living beyond 5 year. Radical surgical resection, which will be referred to as curative intent surgery, is considered to be the only curative option in the treatment of pancreatic cancer.
Improvement in mortality and survival at high-volume center has led to increased use of surgical resection for this disease. To analyze survival rate between the resected group and the unresected group of pancreatic cancer following operation, Methods : Operation was performed in 70 patients with pancreatic cancer from 1998 to 2002. To determine clinicopathological characteristics and survival rates, medical records were reviewed and the postoperative follow up results were analyzed. Statistics was analyzed by SPSS 12.0 for window. Survival rates were analyzed by Kaplan Meier method and Log rank test.
Results : The age was distributed from 35 to 84(mean 57.7 ± 19.8). Male to female sex ratio was 1.1 : 1. The most common location of tumor was head, which was 74.3% (52/70). Of the head lesion, 48 cases was performed the operation. The resection rate was 27% (13/48). Palliative operation rated was 72.9%(35/48). The incidence of postoperative complication was 30%(4/13) in resected group. Perioperative Mortality was 0% in this study. One year and 2 year overall survial rates were 19.6% and 3.2%, respectively. In resected group, One and 2 year survival rate were 40.0% and 20.0%, in unresected group, one and 2 year survival rate were 24.2% and 0%, respectively. There was no statistically significance of survival rate between resection group and non-resected group(p>0.05). But, the only patient who survived over 30 months was seen in resected group.
Conclusion : Prognosis of pancreatic cancer is still poor and resectabiliyy of pancreas remained very low. The only chance of long term survival is early detection and curative resection.

영어초록

Background : Pancreatic cancer is a common and highly fatal malignancy. Long-term survival is rare with only 5 % of patients living beyond 5 year. Radical surgical resection, which will be referred to as curative intent surgery, is considered to be the only curative option in the treatment of pancreatic cancer.
Improvement in mortality and survival at high-volume center has led to increased use of surgical resection for this disease. To analyze survival rate between the resected group and the unresected group of pancreatic cancer following operation, Methods : Operation was performed in 70 patients with pancreatic cancer from 1998 to 2002. To determine clinicopathological characteristics and survival rates, medical records were reviewed and the postoperative follow up results were analyzed. Statistics was analyzed by SPSS 12.0 for window. Survival rates were analyzed by Kaplan Meier method and Log rank test.
Results : The age was distributed from 35 to 84(mean 57.7 ± 19.8). Male to female sex ratio was 1.1 : 1. The most common location of tumor was head, which was 74.3% (52/70). Of the head lesion, 48 cases was performed the operation. The resection rate was 27% (13/48). Palliative operation rated was 72.9%(35/48). The incidence of postoperative complication was 30%(4/13) in resected group. Perioperative Mortality was 0% in this study. One year and 2 year overall survial rates were 19.6% and 3.2%, respectively. In resected group, One and 2 year survival rate were 40.0% and 20.0%, in unresected group, one and 2 year survival rate were 24.2% and 0%, respectively. There was no statistically significance of survival rate between resection group and non-resected group(p>0.05). But, the only patient who survived over 30 months was seen in resected group.
Conclusion : Prognosis of pancreatic cancer is still poor and resectabiliyy of pancreas remained very low. The only chance of long term survival is early detection and curative resection.

참고자료

· 없음