아스피린의 심혈관질환 및 암 예방효과 (Aspirin in the prevention of cardiovascular disease and cancer)

서지정보

· 발행기관 : 대한의사협회
· 수록지 정보 : 대한의사협회지 / 57권 / 4호 / 348 ~ 356페이지
· 저자명 : 백유진, 윤종률

초록

Cardiovascular disease (CVD) is the one of the leading causes of death in Korea. Aspirin, well known for its antiplateletfunction, has been used for the secondary prevention of CVD during the first few several decades. However, whetheror not to have a protective effect on the primary prevention of CVD in apparently healthy people is still controversial.
In addition, accumulating data suggest aspirin may have a favorable possibility on cancer incidence and mortality. Wereviewed the literature, focusing on new evidence on the benefits and risks of aspirin for the prevention of CVD andcancer. Aspirin modestly decreases the risk of non-fatal myocardial infarction and cancer incidence in patients withoutovert CVD and at average cancer risk, but increase the risk of major bleeding. Several guidelines on the use of aspirinfor the primary prevention of CVD stated the need for the prudent assessment of individual CVD risks in the targetpopulation. Currently there's no CVD risk assessment tools based on domestic data available in Korea. Also the bleedingrisk and relatively high incidence of hemorrhagic stroke in Koreans make a difficult decision. Clinicians should give thepatients a balanced information and discuss the effects or harms of taking aspirin on the prevention of CVD and canceraccording to the updated evidence. Patient education for the prevention of CVD is more important and life style changeincluding smoking cessation, weight reduction, and a healthy diet should be emphasized before considering aspirin.

영어초록

Cardiovascular disease (CVD) is the one of the leading causes of death in Korea. Aspirin, well known for its antiplateletfunction, has been used for the secondary prevention of CVD during the first few several decades. However, whetheror not to have a protective effect on the primary prevention of CVD in apparently healthy people is still controversial.
In addition, accumulating data suggest aspirin may have a favorable possibility on cancer incidence and mortality. Wereviewed the literature, focusing on new evidence on the benefits and risks of aspirin for the prevention of CVD andcancer. Aspirin modestly decreases the risk of non-fatal myocardial infarction and cancer incidence in patients withoutovert CVD and at average cancer risk, but increase the risk of major bleeding. Several guidelines on the use of aspirinfor the primary prevention of CVD stated the need for the prudent assessment of individual CVD risks in the targetpopulation. Currently there's no CVD risk assessment tools based on domestic data available in Korea. Also the bleedingrisk and relatively high incidence of hemorrhagic stroke in Koreans make a difficult decision. Clinicians should give thepatients a balanced information and discuss the effects or harms of taking aspirin on the prevention of CVD and canceraccording to the updated evidence. Patient education for the prevention of CVD is more important and life style changeincluding smoking cessation, weight reduction, and a healthy diet should be emphasized before considering aspirin.

참고자료

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