Magnetic Resonance Imaging of Breast Cancer Patients with BRCA Mutation

서지정보

· 발행기관 : 대한자기공명의과학회
· 수록지 정보 : Investigative Magnetic Resonance Imaging / 17권 / 3호 / 207 ~ 214페이지
· 저자명 : 정선영, 차주희, 김학희, 신희정, 김현지, 채은영, 신지은, 최우정, 홍민지, 안세현, 이종원, 정경해

초록

Purpose : To evaluate the MRI findings of breast cancer with BRCA mutation.
Materials and Methods: We collected information of the breast cancer patients who underwent the test for BRCA gene mutation as well as preoperative breast MRI from January 2007 to December 2010. A total of 185 patients were enrolled;33 of these patients had BRCA mutations and 152 patients did not. Among them, a total of 231 breast cancers were detected. Images of the 47 breast cancers with BRCA mutation and of the 184 breast cancers without mutations were evaluated to compare the morphologic and enhancement features on MRI.
Results: With MR imaging, there were no significant difference in morphologic characteristic between two groups.
However, enhancement pattern in the group with BRCA mutation were more likely to have persistent enhancement (p <0.233), and LN metastasis was more common in breast cancers without BRCA mutation. Breast cancers with BRCA 2mutation tend to show more persistent enhancement pattern than BRCA 1 mutation.
Conclusion: In breast cancer patients with BRCA mutation, MRI didn’t show significant difference in morphologic characteristics,however breast cancers with BRCA gene mutation carriers tend to have benign morphologic features on MRI,such as Type 1 kinetic curve enhancement.

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