괄루근의 항알러지 및 피부염증에 미치는 영향 (Effect of Trichosanthis Radix Extract on Anti-allergy and Skin Inflammation)

서지정보

· 발행기관 : 한국미용학회
· 수록지 정보 : 한국미용학회지 / 30권 / 5호 / 1035 ~ 1041페이지
· 저자명 : 백원진, 윤미영

초록

This study was conducted to study the effects of TR-W and TR-E on anti-allergy and skin inflammation inhibition. In order to check the concentration used in the experiment and its toxicity to cells, RBL-2H3 cells and HMC-1 cells were treated with TR-W and TR-E at different concentrations and tested at a concentration of 100 mg/ml or less, which does not affect the survival rate. proceeded. In order to determine the effect on the inflammatory response to mast cells, the inflammatory cytokines TNF-α, IL-8, and IL-6 were measured. As a result, TR-W and TR were found in TNF-α and IL-8, which promote the early inflammatory response. -E showed a significant effect at 100 mg/ml, and TR-E showed a significant effect at 50 mg/ml, showing the effect even at a lower concentration than TR-W. IL-6, which is involved in causing allergic dermatitis, showed a significant effect at 100 and 50 mg/ml in TR-W and TR- E, indicating that it is effective in suppressing inflammation in TR-W and TR-E. In addition, histamine and β-hexosaminidase, which are inflammatory mediators involved in the initial allergic reaction, were significantly suppressed at 100 and 50 mg/ml in TR-W and TR-E, demonstrating anti-allergy effect. These research results are believed to have the highest utility value as a functional cosmetic material in the future, and additional research is considered necessary.

영어초록

This study was conducted to study the effects of TR-W and TR-E on anti-allergy and skin inflammation inhibition. In order to check the concentration used in the experiment and its toxicity to cells, RBL-2H3 cells and HMC-1 cells were treated with TR-W and TR-E at different concentrations and tested at a concentration of 100 mg/ml or less, which does not affect the survival rate. proceeded. In order to determine the effect on the inflammatory response to mast cells, the inflammatory cytokines TNF-α, IL-8, and IL-6 were measured. As a result, TR-W and TR were found in TNF-α and IL-8, which promote the early inflammatory response. -E showed a significant effect at 100 mg/ml, and TR-E showed a significant effect at 50 mg/ml, showing the effect even at a lower concentration than TR-W. IL-6, which is involved in causing allergic dermatitis, showed a significant effect at 100 and 50 mg/ml in TR-W and TR- E, indicating that it is effective in suppressing inflammation in TR-W and TR-E. In addition, histamine and β-hexosaminidase, which are inflammatory mediators involved in the initial allergic reaction, were significantly suppressed at 100 and 50 mg/ml in TR-W and TR-E, demonstrating anti-allergy effect. These research results are believed to have the highest utility value as a functional cosmetic material in the future, and additional research is considered necessary.

참고자료

· 없음