마우스에서 히알우론산 나트륨이 항염효과에 미치는 영향에 관한 연구 (The effect of hyaluronic acid on anti-inflammatory action in mouse)

서지정보

· 발행기관 : 대한구강악안면외과학회
· 수록지 정보 : 대한구강악안면외과학회지 / 36권 / 1호 / 16 ~ 22페이지
· 저자명 : 김상균, 이형석, 변광섭, 이영주, 홍순민, 최미라, 박준우

초록

Purpose: The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-1β(IL-1β), cyclooxygenase2 (COX-2)and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse.
Material and methods: Mice of this study were devided into 4 groups: Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply).
Results: Hyaluronic group showed less expressions of IL-1β, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope.
Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope.
Conclusion: It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.

영어초록

Purpose: The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-1β(IL-1β), cyclooxygenase2 (COX-2)and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse.
Material and methods: Mice of this study were devided into 4 groups: Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply).
Results: Hyaluronic group showed less expressions of IL-1β, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope.
Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope.
Conclusion: It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.

참고자료

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