쌀 배아와 흑미 미강 색소 첨가 배아젤리가 고콜레스테롤 식이 흰쥐의 지질대사와 항산화효소 활성에 미치는 영향 (Effects of Rice Embryo and Embryo Jelly with Black Rice Bran Pigment on Lipid Metabolism and Antioxidant Enzyme Activity in High Cholesterol-Fed Rats)

서지정보

· 발행기관 : 한국응용생명화학회
· 수록지 정보 : Applied Biological Chemistry / 51권 / 3호 / 200 ~ 206페이지
· 저자명 : 강미영, 조민경, 김미현

초록

We investigated the effect of rice embryo and embryo jelly with black rice bran pigment on lipid
metabolism and antioxidant activity. Thirty 4-week-old male Sprague-Dawley rats were fed high
cholesterol diets supplemented with 15% rice embryo and 25% embryo jelly added black rice bran
pigment, respectively, for 6 weeks. Plasma and hepatic lipid profile, lipid peroxidation, and the
activity of antioxidant scavenger enzymes in liver were examined. Supplementation with rice
embryo and embryo jelly had no effect on food intakes in high cholesterol-fed rats. The plasma
triglyceride concentration was not significantly different among the groups. Supplementation with
rice embryo and embryo jelly resulted in lower plasma and hepatic total cholesterol (TC) concentration
and high-density lipoprotein-cholesterol (HDL-C)/TC ratio and atherogenic index compared
to the control group, while the plasma HDL-C concentration tended to elevated. Rice embryo and
embryo jelly tended to lower plasma and hepatic levels of thiobarbituric acid reactive substances
than the control group. Moreover, hepatic antioxidant enzyme activities, including superoxide dismutase
and glutathione peroxidase, were significantly higher in the rice embryo and embryo jelly
groups. In conclusion, rice embryo and embryo jelly was very effective in improving the lipid
metabolism and reducing oxidative stress by up-regulating the hepatic antioxidant enzymes in high
cholesterol-fed rats.

영어초록

We investigated the effect of rice embryo and embryo jelly with black rice bran pigment on lipid
metabolism and antioxidant activity. Thirty 4-week-old male Sprague-Dawley rats were fed high
cholesterol diets supplemented with 15% rice embryo and 25% embryo jelly added black rice bran
pigment, respectively, for 6 weeks. Plasma and hepatic lipid profile, lipid peroxidation, and the
activity of antioxidant scavenger enzymes in liver were examined. Supplementation with rice
embryo and embryo jelly had no effect on food intakes in high cholesterol-fed rats. The plasma
triglyceride concentration was not significantly different among the groups. Supplementation with
rice embryo and embryo jelly resulted in lower plasma and hepatic total cholesterol (TC) concentration
and high-density lipoprotein-cholesterol (HDL-C)/TC ratio and atherogenic index compared
to the control group, while the plasma HDL-C concentration tended to elevated. Rice embryo and
embryo jelly tended to lower plasma and hepatic levels of thiobarbituric acid reactive substances
than the control group. Moreover, hepatic antioxidant enzyme activities, including superoxide dismutase
and glutathione peroxidase, were significantly higher in the rice embryo and embryo jelly
groups. In conclusion, rice embryo and embryo jelly was very effective in improving the lipid
metabolism and reducing oxidative stress by up-regulating the hepatic antioxidant enzymes in high
cholesterol-fed rats.

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