Cerebellar Activation Related to Various Tasks Using fMRI

서지정보

· 발행기관 : 대한자기공명의과학회
· 수록지 정보 : Investigative Magnetic Resonance Imaging / 13권 / 1호 / 47 ~ 53페이지
· 저자명 : 황승배, 곽효성, 이상용, 진공용, 한영민, 정경호, 김영곤

초록

Purpose : Although it’s been known for half a century that unique structures have evolved in the cerebellum and they then became greatly enlarged in the human brain, the function of these structures still remains unknown. The purpose of this study was to assess cerebellar activation during motor, sensory, word generation, listening comprehension, and working memory tasks with using functional magnetic resonance imaging (fMRI).
Materials and Methods : Eleven healthy right-handed subjects (Male: female, 6:5, mean age: 27.4years) were imaged on a Siemens 1.5T scanner. Whole brain functional maps were acquired using BOLD EPI sequences in the axial plane. Each paradigm consisted of five epochs of activation vs. the control condition. The activation tasks consisted of left finger complex movement, sensory stimulation of the left hand, word generation, listening comprehension, and working memory tasks. The reference function was a boxcar waveform. The activation maps were thresholded at p = 0.001. SPM 5 evaluated the activated areas and responses within the cerebellum.
Results : Cerebellar activation was observed on motor task, word generation task, and working memory task. There were 949 activated areas and the mean fitted and adjusted response was 0.68 during the motor task. There were 319 activated areas and the mean fitted and adjusted response was 0.15 during the word generation task. There were 330 activated areas and the mean fitted and adjusted response was 0.26 during the working memory task.
Conclusion : Our results suggest that the cerebellum is involved in a variety of
functional tasks, including motor, word generation, and working memory tasks.
However, during the motor task, the cerebellum showed a large activated area and a high response. Cerebellar function can be evaluated by fMRI.

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