예측 불가능한 약물유해반응의 임상양상 및 약물 인과성 평가 (Clinical Aspects of Unpredictable Adverse Drug Reaction and Assessment of Drug Casuality)

서지정보

· 발행기관 : 한국병원약사회
· 수록지 정보 : 병원약사회지 / 35권 / 3호 / 331 ~ 339페이지
· 저자명 : 김광준, 최인, 권용은

초록

Objective : The aim of this study was to provide basic data for predicting adverse drug reaction (ADR) by investigating drugs that cause type B ADR, the related clinical features and the frequency by age group.
Methods : We retrospectively investigated the ADR reported from August 2015 to July 2016 at Chosun University Hospital Regional Drug Safety Center using electronic medical records. The type and clinical features of type B ADR were investigated. The Naranjo scale score was used to evaluate the ADR.
Results : During the study period, 26,362 patients were hospitalized and 4,110 (15.6%) adverse drug reactions were reported. The incidence of Type B ADRs was rated as 6.6% (269 cases). Due to the results of casualty assessment with drug, 190 cases (70.6%) were categorized as “possible”, 61 cases (22.7%)“ probable”and 17 cases (6.3%)“ definite”. The incidence of type B ADR was slightly higher in females (140 cases, 52.0%) than in males (129 cases, 48.0%). According to the hypersensitivity, 117 cases (43.5%) showed true allergic reaction when 99 cases (36.8%) showed pseudoallergic reaction.
Antibiotics (100 cases, 37.2%), contrast agents (55 cases, 20.4%) and analgesics (39 cases, 14.5%) were the causes of type B ADR. Moreover, type B ADR was mainly reported in the age groups of 40s (48 cases, 17.8%), 50s (62 cases, 23.0%), 60s (34 cases, 12.6%) and 70s (38 cases, 14.1%).
Conclusions : When patients take medications that have a type B ADR risk of occurrence, it is necessary to evaluate the patient medication history. Based on this evaluation, an antibiotic skin test and sufficient pretreatment process should be carried out to prevent drug side effects. Furthermore, pharmacist’s efforts are needed to provide adequate information on ADR.

영어초록

Objective : The aim of this study was to provide basic data for predicting adverse drug reaction (ADR) by investigating drugs that cause type B ADR, the related clinical features and the frequency by age group.
Methods : We retrospectively investigated the ADR reported from August 2015 to July 2016 at Chosun University Hospital Regional Drug Safety Center using electronic medical records. The type and clinical features of type B ADR were investigated. The Naranjo scale score was used to evaluate the ADR.
Results : During the study period, 26,362 patients were hospitalized and 4,110 (15.6%) adverse drug reactions were reported. The incidence of Type B ADRs was rated as 6.6% (269 cases). Due to the results of casualty assessment with drug, 190 cases (70.6%) were categorized as “possible”, 61 cases (22.7%)“ probable”and 17 cases (6.3%)“ definite”. The incidence of type B ADR was slightly higher in females (140 cases, 52.0%) than in males (129 cases, 48.0%). According to the hypersensitivity, 117 cases (43.5%) showed true allergic reaction when 99 cases (36.8%) showed pseudoallergic reaction.
Antibiotics (100 cases, 37.2%), contrast agents (55 cases, 20.4%) and analgesics (39 cases, 14.5%) were the causes of type B ADR. Moreover, type B ADR was mainly reported in the age groups of 40s (48 cases, 17.8%), 50s (62 cases, 23.0%), 60s (34 cases, 12.6%) and 70s (38 cases, 14.1%).
Conclusions : When patients take medications that have a type B ADR risk of occurrence, it is necessary to evaluate the patient medication history. Based on this evaluation, an antibiotic skin test and sufficient pretreatment process should be carried out to prevent drug side effects. Furthermore, pharmacist’s efforts are needed to provide adequate information on ADR.

참고자료

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