태아기 성호르몬이 여성의 알츠하이머병의 발병에 미치는 영향: 2D/4D 손가락 길이 비율을 이용한 단면 연구 (Effect of Fetal Sex Hormone on the Development of Alzheimer’s Disease in Woman: A Cross-Sectional Study Using 2D/4D Digit Length Ratio)

서지정보

· 발행기관 : 대한노인정신의학회
· 수록지 정보 : 노인정신의학 / 24권 / 2호 / 99 ~ 102페이지
· 저자명 : 강태욱, 이영민, 박제민, 이병대, 문은수, 정희정, 김수연, 이강윤, 서화규, 정영인

초록

Objective: The purpose of this study is to investigate an association between sex-hormone exposure during fetal period and the development of Alzheimer’s disease (AD).
Methods: Twenty four AD patients and 25 normal controls were included from Memory Impairment Clinic of Pusan National University Hospital in Korea. Subjects are measured the ratio of the length of the second to the fourth digit (2D/4D) to estimate fetal sex-hormone exposure. Analysis of covariance was used to investigate an association between fetal sex-hormone exposure and the development of AD after adjusting age, education level, Korean Mini-Mental Status Examination and head circumference.
Results: We found that the females with AD had significantly lower 2D/4D ratios than the female controls. In the females with AD, the 2D/4D ratios in the left hand was 0.021 and 0.017 in the right hand compared with the controls.
Conclusion: Our findings suggest that the development of AD in female may be related with higher testosterone and lower estrogen exposure during fetal period.

영어초록

Objective: The purpose of this study is to investigate an association between sex-hormone exposure during fetal period and the development of Alzheimer’s disease (AD).
Methods: Twenty four AD patients and 25 normal controls were included from Memory Impairment Clinic of Pusan National University Hospital in Korea. Subjects are measured the ratio of the length of the second to the fourth digit (2D/4D) to estimate fetal sex-hormone exposure. Analysis of covariance was used to investigate an association between fetal sex-hormone exposure and the development of AD after adjusting age, education level, Korean Mini-Mental Status Examination and head circumference.
Results: We found that the females with AD had significantly lower 2D/4D ratios than the female controls. In the females with AD, the 2D/4D ratios in the left hand was 0.021 and 0.017 in the right hand compared with the controls.
Conclusion: Our findings suggest that the development of AD in female may be related with higher testosterone and lower estrogen exposure during fetal period.

참고자료

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