당뇨병이 없는 성인에서 심혈관질환 위험요소 및 대사증후군과 당화혈색소의 상관관계 (Association of Hemoglobin A1c with Cardiovascular Disease Risk Factors and Metabolic Syndrome in Nondiabetic Adults)

서지정보

· 발행기관 : 대한당뇨병학회
· 수록지 정보 : Diabetes and Metabolism Journal / 32권 / 5호 / 435 ~ 444페이지
· 저자명 : 김진화, 최소라, 이재록, 신지혜, 이상준, 한미아, 박종, 배학연, 김상용

초록

Background: Glycosylated hemoglobin (HbA1c) is a useful index of mean blood glucose concentrations over
the preceding 2 to 3 months. Elevated HbA1c levels (> 7%) are associated with a higher incidence of
microvascular and macrovascular complications in patients with diabetes mellitus. However, the relationship
between HbA1c and cardiovascualr disease risk in nondiabetic adults has been unclear. The aim of this study
is to estimate the association of HbA1c with cardiovascular disease risk factors and metabolic syndrome in
nondiabetic adults.
Methods: The subjects of this study included 533 adults (180 males and 353 females) aged 20~70 years (mean
age: 46.9 ± 10.12 years) without previously diagnosed diabetes who lived in Kangyang country. We
examined baseline HbA1c levels and cardiovascular risk factors. Metabolic syndrome was defined based on
International Diabetes Federation guidelines.
Results: The prevalence of metabolic syndrome significantly increased as HbA1c increased. HbA1c revealed
a significant correlation with age (r = 0.258, P < 0.001), BMI (r = 0.152, P < 0.001), waist circumference (r =
0.252, P < 0.001), fasting plasma glucose (r = 0.319, P < 0.001), systolic (r = 0.100, P = 0.021), diastolic (r =
0.115, P = 0.008) blood pressure, total cholesterol (r = 0.232, P < 0.001), triglyceride (r = 0.156, P < 0.001), LDL
cholesterol (r = 0.216, P < 0.001), and HDL cholesterol (r = -0.167, P < 0.001). Multiple regression analysis
showed that HbA1c had a association with age, fasting plasma glucose, and dyslipidemia. The receiver
operating characterstics (ROC) curve analysis determined HbA1c of 5.35% to yield optimal sensitivity and
specificity corresponding to the presence of metabolic syndrome.
Conclusion: The HbA1c level is correlated with cardiovascular risk factors and prevalence of metabolic
syndrome in nondiabetic adults. (KOREAN DIABETES J 32:435-444, 2008)

영어초록

Background: Glycosylated hemoglobin (HbA1c) is a useful index of mean blood glucose concentrations over
the preceding 2 to 3 months. Elevated HbA1c levels (> 7%) are associated with a higher incidence of
microvascular and macrovascular complications in patients with diabetes mellitus. However, the relationship
between HbA1c and cardiovascualr disease risk in nondiabetic adults has been unclear. The aim of this study
is to estimate the association of HbA1c with cardiovascular disease risk factors and metabolic syndrome in
nondiabetic adults.
Methods: The subjects of this study included 533 adults (180 males and 353 females) aged 20~70 years (mean
age: 46.9 ± 10.12 years) without previously diagnosed diabetes who lived in Kangyang country. We
examined baseline HbA1c levels and cardiovascular risk factors. Metabolic syndrome was defined based on
International Diabetes Federation guidelines.
Results: The prevalence of metabolic syndrome significantly increased as HbA1c increased. HbA1c revealed
a significant correlation with age (r = 0.258, P < 0.001), BMI (r = 0.152, P < 0.001), waist circumference (r =
0.252, P < 0.001), fasting plasma glucose (r = 0.319, P < 0.001), systolic (r = 0.100, P = 0.021), diastolic (r =
0.115, P = 0.008) blood pressure, total cholesterol (r = 0.232, P < 0.001), triglyceride (r = 0.156, P < 0.001), LDL
cholesterol (r = 0.216, P < 0.001), and HDL cholesterol (r = -0.167, P < 0.001). Multiple regression analysis
showed that HbA1c had a association with age, fasting plasma glucose, and dyslipidemia. The receiver
operating characterstics (ROC) curve analysis determined HbA1c of 5.35% to yield optimal sensitivity and
specificity corresponding to the presence of metabolic syndrome.
Conclusion: The HbA1c level is correlated with cardiovascular risk factors and prevalence of metabolic
syndrome in nondiabetic adults. (KOREAN DIABETES J 32:435-444, 2008)

참고자료

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