123I-FP-CIT SPECT를 이용한 다중계위축증 및 조기 파킨슨병에서의 평가 (Evaluation of Multiple System Atrophy and Early Parkinson’s Disease Using 123I-FP-CIT SPECT)

서지정보

· 발행기관 : 대한핵의학회
· 수록지 정보 : Nuclear Medicine and Molecular Imaging / 43권 / 1호 / 10 ~ 18페이지
· 저자명 : 오소원, 김유경, 이병철, 김범산, 김지선, 김종민, 김상은

초록

Purpose: We investigated quantification of dopaminergic transporter (DAT) and serotonergic transporter (SERT) on 123I-FP-CIT SPECT for differentiating between multiple systemic atrophy (MSA) and idiopathic Parkinson’s disease (IPD). Materials and Methods: N–fluoropropyl-2β-carbomethoxy-3β-4-[123I]-iodophenylnortropane SPECT (123I-FP-CIT SPECT) was performed in 8 patients with MSA (mean age: 64.0±4.5yrs, m:f=6:2), 13 with early IPD (mean age: 65.5±5.3yrs, m:f=9:4), and 12 healthy controls (mean age: 63.3±5.7yrs, m:f=8:4). Standard regions of interests (ROIs) of striatum to evaluate DAT, and hypothalamus and midbrain for SERT were drawn on standard template images and applied to each image taken 4 hours after radiotracer injection. Striatal specific binding for DAT and hypothalamic and midbrain specific binding for SERT were calculated using region/reference ratio based on the transient equilibrium method. Group differences were tested using ANOVA with the postHoc analysis. Results: DAT in the whole striatum and striatal subregions were significantly decreased in both patient groups with MSA and early IPD, compared with healthy control (p<0.05 in all). In early IPD, a significant increase in the uptake ratio in anterior and posterior putamen and a trend of increase in caudate to putamen ratio was observed. In MSA, the decrease of DAT was accompanied with no difference in the striatal uptake pattern compared with healthy controls. Regarding the brain regions where 123I-FP-CIT binding was predominant by SERT, MSA patients showed a decrease in the binding of 123I-FP-CIT in the pons compared with controls as well as early IPD patients (MSA: 0.22±0.1 healthy controls: 0.33±0.19, IPD: 0.29±0.19), however, it did not reach the statistical significance. Conclusion: In this study, the differential patterns in the reduction of DAT in the striatum and the reduction of pontine 123I- FP-CIT binding predominant by SERT could be observed in MSA patients on 123I- FP-CIT SPECT. We suggest that the quantification of SERT as well as DAT using 123I- FP-CIT SPECT is helpful to differentiate parkinsonian disorders in early stage.

영어초록

Purpose: We investigated quantification of dopaminergic transporter (DAT) and serotonergic transporter (SERT) on 123I-FP-CIT SPECT for differentiating between multiple systemic atrophy (MSA) and idiopathic Parkinson’s disease (IPD). Materials and Methods: N–fluoropropyl-2β-carbomethoxy-3β-4-[123I]-iodophenylnortropane SPECT (123I-FP-CIT SPECT) was performed in 8 patients with MSA (mean age: 64.0±4.5yrs, m:f=6:2), 13 with early IPD (mean age: 65.5±5.3yrs, m:f=9:4), and 12 healthy controls (mean age: 63.3±5.7yrs, m:f=8:4). Standard regions of interests (ROIs) of striatum to evaluate DAT, and hypothalamus and midbrain for SERT were drawn on standard template images and applied to each image taken 4 hours after radiotracer injection. Striatal specific binding for DAT and hypothalamic and midbrain specific binding for SERT were calculated using region/reference ratio based on the transient equilibrium method. Group differences were tested using ANOVA with the postHoc analysis. Results: DAT in the whole striatum and striatal subregions were significantly decreased in both patient groups with MSA and early IPD, compared with healthy control (p<0.05 in all). In early IPD, a significant increase in the uptake ratio in anterior and posterior putamen and a trend of increase in caudate to putamen ratio was observed. In MSA, the decrease of DAT was accompanied with no difference in the striatal uptake pattern compared with healthy controls. Regarding the brain regions where 123I-FP-CIT binding was predominant by SERT, MSA patients showed a decrease in the binding of 123I-FP-CIT in the pons compared with controls as well as early IPD patients (MSA: 0.22±0.1 healthy controls: 0.33±0.19, IPD: 0.29±0.19), however, it did not reach the statistical significance. Conclusion: In this study, the differential patterns in the reduction of DAT in the striatum and the reduction of pontine 123I- FP-CIT binding predominant by SERT could be observed in MSA patients on 123I- FP-CIT SPECT. We suggest that the quantification of SERT as well as DAT using 123I- FP-CIT SPECT is helpful to differentiate parkinsonian disorders in early stage.

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