신경인지검사 성적의 개인 내 변산성 : 조현병 환자, 형제자매 및 대조군 비교 (Intra-Individual Neuropsychological Test Variability : A Comparison of Patients with Schizophrenia, Their Siblings, and Healthy Controls)

서지정보

· 발행기관 : 대한신경정신의학회
· 수록지 정보 : 신경정신의학 / 53권 / 6호 / 379 ~ 385페이지
· 저자명 : 오혜지, 홍경수, 이건석, 유승형, 노지혜, 박주현, 최홍, 김지혜

초록

본 연구는 조현병과 관련되어 나타나는 인지기능 결함을확인하였다. 환자군은 인지 영역간의 개인 내 변산성이 크게나타나 수행의 불균형이 두드러졌으며 특히 유병기간이 11년 이상으로 만성화된 환자일수록 개인 내 변산성이 큰 것으로 나타났다. 또한 다른 인지 영역과 달리 처리 속도 영역에서만 소검사 간 개인 내 변산성은 환자, 형제자매, 대조군순서로 크고 환자들도 유병기간이 길어질수록 큰 것으로 나타났다. 이러한 인지적 특성이 조현병 환자의 인지기능을 이해하는 데 도움을 줄 것으로 생각된다.

영어초록

Objectives Intra-individual variability of cognitive performance across different tests or domains has been reported as an important index of cognitive function. The aim of the current study is to examine the intra-individual variability across different cognitive domains and tests in patients with schizophrenia, their unaffected siblings, and normal controls. We also compared the variability among three patient sub-groups divided according to the duration of illness.
Methods Comprehensive neurocognitive tests were administered in order to stabilize patients with schizophrenia (n=129), healthy siblings (n=38) of the patients, and normal controls (n=110). Intra-individual variability was computed from the variance of the scores of six cognitive domains of the Measurement and Treatment Research to Improve Cognition in Schizophrenia consensus battery. We examined intra-individual variability across six factor-based cognitive scores and individual test scores of each cognitive domain.
Results Compared to the normal control and sibling groups, patients showed significantly increased intra-individual variability across six cognitive domains and individual cognitive tests of each domain. Compared to the normal control, siblings showed significantly increased intra-individual variability only across individual tests of the processing of speed domain. Among patient sub-groups, those with the longest duration of illness (≥11 years) showed significantly higher intra-individual variability across six cognitive domains and across individual tests of the processing of speed domain compared to the other two groups.
Conclusion This study identified cognitive dissonances across six cognitive domain schizophrenia patients. These cognitive characteristics were not observed in the sibling groups and seemed to progress during the course of illness.

참고자료

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