알츠하이머병의 위험인자 및 인지기능의 남녀성별차이:이화치매클리닉 (Gender Differences in Risk Factor Prevalence and Cognitive Functions in Alzheimer’s Disease ; Experience of Ewha Dementia Clinic)

서지정보

· 발행기관 : 대한치매학회
· 수록지 정보 : Dementia and Neurocognitive Disorders(대한치매학회지) / 6권 / 2호 / 34 ~ 37페이지
· 저자명 : 고승아, 윤지영, 정지향

초록

Background: The gender difference in Alzheimer’s disease(AD) is well known but not yet systematically reviewed in Korean dementia population. Our study is a step forward for gender specific hospital cohort for development of future specific treatment plan with regard to gender difference in risk factors prevalence and cognitive functions in the patients with AD..
Method: Of total 250 Dementia Cohort from October 2002 to July 2005, 65 AD patients were reanalyzed for the study. DSM-IV and NINDS-ADRDA criteria were used for clinical probable AD. All patients had thorough clinical evaluation, standard neuropsychological tests, laboratory evaluations to rule out other possible cause of dementia and a brain MRI at the time of initial evaluations. The risk factors including age, education, previous head trauma, hypertension, diabetes, hyperlipidemia, heart disease, previous stroke, heavy alcohol consumption, positive family history were compared in gender groups.
Result: In 65 AD patient, 18(27.7%) patient were male with mean ages of 75.6±7.8 and mean education levels were 7.6±4.5, MMSE scores was 19.8±5.3 and CDR was 1.4±0.8. 47(73.3%) patient were female with mean ages of 75.7±9.3 and mean education levels were 4.6±3.8, MMSE scores was 18±5.6 and CDR was 1.3±0.8. Mean age, MMSE scores, and CDR between genders were similar, but education levels were significantly higher in male gender (p value<0.05). Hypertension and previous stroke is related to more AD in female gender by Odd Ratio analysis (p value<0.05). But smoking, alcohol consumption were more prevalent in male patient (p value <0.05) by chi square analysis.
Conclusion: The gender difference with regard to risk factor prevalence were demonstrated in this study, but epidemiologic significance awaits further study based on population based cohort.

영어초록

Background: The gender difference in Alzheimer’s disease(AD) is well known but not yet systematically reviewed in Korean dementia population. Our study is a step forward for gender specific hospital cohort for development of future specific treatment plan with regard to gender difference in risk factors prevalence and cognitive functions in the patients with AD..
Method: Of total 250 Dementia Cohort from October 2002 to July 2005, 65 AD patients were reanalyzed for the study. DSM-IV and NINDS-ADRDA criteria were used for clinical probable AD. All patients had thorough clinical evaluation, standard neuropsychological tests, laboratory evaluations to rule out other possible cause of dementia and a brain MRI at the time of initial evaluations. The risk factors including age, education, previous head trauma, hypertension, diabetes, hyperlipidemia, heart disease, previous stroke, heavy alcohol consumption, positive family history were compared in gender groups.
Result: In 65 AD patient, 18(27.7%) patient were male with mean ages of 75.6±7.8 and mean education levels were 7.6±4.5, MMSE scores was 19.8±5.3 and CDR was 1.4±0.8. 47(73.3%) patient were female with mean ages of 75.7±9.3 and mean education levels were 4.6±3.8, MMSE scores was 18±5.6 and CDR was 1.3±0.8. Mean age, MMSE scores, and CDR between genders were similar, but education levels were significantly higher in male gender (p value<0.05). Hypertension and previous stroke is related to more AD in female gender by Odd Ratio analysis (p value<0.05). But smoking, alcohol consumption were more prevalent in male patient (p value <0.05) by chi square analysis.
Conclusion: The gender difference with regard to risk factor prevalence were demonstrated in this study, but epidemiologic significance awaits further study based on population based cohort.

참고자료

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