직장암 치료 중 진단된 만성호중구성백혈병 1예 (Incidentally Found Chronic Neutrophilic Leukemia in a Patient with Rectal Cancer)

서지정보

· 발행기관 : 대한내과학회
· 수록지 정보 : 대한내과학회지 / 90권 / 1호 / 59 ~ 62페이지
· 저자명 : 김석형, 박해열, 황창혁, 정영학, 이민주, 최성은, 김유리

초록

증례는 감염 및 악성종양과 동반되어 백혈병양 반응과의감별이 어려웠고, 또한 악성종양의 전이와 유사하게 종괴를형성하여 더욱 감별이 어려웠던 CNL 1예를 경험하였기에문헌고찰과 함께 보고하는 바이다.

영어초록

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm characterized by sustained neutrophilia, splenomegaly, and hypercellular bone marrow without Philadelphia chromosome. Diagnosis of CNL requires exclusion of identifiable causes of reactive neutrophilia, such as infection and tumors. Our patient presented with general weakness and weight loss. Computed tomography (CT) showed a mass in the distal rectum, which was confirmed to be an adenocarcinoma by colonoscopic biopsy.
Positron emission tomography-CT showed multiple liver, bone, and lymph node metastases. Liver and lymph node biopsies revealed neutrophilic infiltration with no evidence of adenocarcinoma. The pathological findings of the bone marrow were compatible with CNL. Cytogenetic analysis revealed a normal karyotype, and molecular analysis was negative for BCR/ABL. Here, we present a 73 year-old man diagnosed with concurrent CNL and rectal cancer.

참고자료

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