파킨슨병 환자에서 보행동결과 인지기능의 연관성 (Freezing of Gait and Cognitive Functions in Patients with Parkinson’s Disease)

서지정보

· 발행기관 : 대한치매학회
· 수록지 정보 : Dementia and Neurocognitive Disorders(대한치매학회지) / 8권 / 1호 / 67 ~ 73페이지
· 저자명 : 박희경, 유종윤, 이숙정, 김성렬, 김미정, 권미선, 이재홍, 이명종, 정선주

초록

Background: Freezing of gait (FOG) in Parkinson’s disease (PD) is a unique motor symptom,
representing the breakdown of essential components of gait. We aimed to study the correlation
between FOG and cognitive functions, particularly focusing on frontal and parietal functions, in
patients with PD. Methods: We prospectively studied 25 patients with PD, including 15 PD patients
with freezing (PDF) and 10 PD patients without freezing (PDNF). Gait analysis was performed
with 3-dimensional gait analysis system that includes six cameras. The frequency of freezing
episodes per one cycle, total step numbers per one cycle, and total time of one gait cycle were
evaluated. All patients were evaluated with K-MMSE, Montreal Cognitive Assessment-Korean
(MoCA-K), and Rey Complex Figure Test (RCFT). Results: In PDF, there was significant improvement
in total step number, total time, gait velocity, cadence, and stride length after using visual
cue. For auditory cue, in PDF, there was significant improvement in total step number, total
time, freezing number, and cadence. FOG in PD was associated with some aspects of frontal
dysfunction. However, there was no significant correlation between gait features and other cognitive
tests, including total scores of K-MMSE, MoCA-K, and RCFT, in both PDF and PDNF. Conclusions:
FOG in PD was significantly improved by external cues. FOG in PD was associated
with some aspects of frontal dysfunction, which warrants for further investigations in detail.

영어초록

Background: Freezing of gait (FOG) in Parkinson’s disease (PD) is a unique motor symptom,
representing the breakdown of essential components of gait. We aimed to study the correlation
between FOG and cognitive functions, particularly focusing on frontal and parietal functions, in
patients with PD. Methods: We prospectively studied 25 patients with PD, including 15 PD patients
with freezing (PDF) and 10 PD patients without freezing (PDNF). Gait analysis was performed
with 3-dimensional gait analysis system that includes six cameras. The frequency of freezing
episodes per one cycle, total step numbers per one cycle, and total time of one gait cycle were
evaluated. All patients were evaluated with K-MMSE, Montreal Cognitive Assessment-Korean
(MoCA-K), and Rey Complex Figure Test (RCFT). Results: In PDF, there was significant improvement
in total step number, total time, gait velocity, cadence, and stride length after using visual
cue. For auditory cue, in PDF, there was significant improvement in total step number, total
time, freezing number, and cadence. FOG in PD was associated with some aspects of frontal
dysfunction. However, there was no significant correlation between gait features and other cognitive
tests, including total scores of K-MMSE, MoCA-K, and RCFT, in both PDF and PDNF. Conclusions:
FOG in PD was significantly improved by external cues. FOG in PD was associated
with some aspects of frontal dysfunction, which warrants for further investigations in detail.

참고자료

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