비만 피험자에서 블록앤번의 유효성 및 안전성을 평가하기 위한 위약대조 비교 인체시험 (Placebo-Controlled Intervention Study for the Efficacy and Safety of Block and Burn® in the Mild Obesity Patient)

서지정보

· 발행기관 : 한국임상약학회
· 수록지 정보 : 한국임상약학회지 / 17권 / 2호 / 130 ~ 137페이지
· 저자명 : 최수영, 김남식, 조병석, 송석길, 이종길, 이명구, 정연복

초록

The purpose of the present study was to evaluate the efficacy and safety of Block and burn®, a 4:1 mixture of Phaseolus vulgaris and Garcinia cambogia extracts, in reducing body weight, as the main outcome measure. Secondary measures of the study were body composition change in overweight human subjects. A randomized, double-blinded, placebocontrolled study was conducted on 52 pre-selected, slightly overweight volunteers, whose weight had been essentially stable for at least 2 weeks, The volunteers were divided into two groups, homogeneous for age, gender, and body weight. The test product (1.2 g) containing Phaseolus vulgaris (200 mg) and Garcinia cambogia (50 mg) and the placebo (1.2 g) were taken 6 tablets per day for 56 consecutive days, respectively. Each subject's body weight, body mass index (BMI), body fat, body fat ratio, and waist hip ratio (WHR) were measured. After 56 days (8 weeks), subjects receiving Block and burn ® had significantly greater reduction of body weight. Moreover, a significant changes of the BMI, body fat, and body fat ratio were observed in the test group compared to placebo. However, WHR was not statistically different between groups. These results indicated that Block and burn® produced significant decrements in body weight and suggested decrements in fat mass in the face of maintained lean body mass.

영어초록

The purpose of the present study was to evaluate the efficacy and safety of Block and burn®, a 4:1 mixture of Phaseolus vulgaris and Garcinia cambogia extracts, in reducing body weight, as the main outcome measure. Secondary measures of the study were body composition change in overweight human subjects. A randomized, double-blinded, placebocontrolled study was conducted on 52 pre-selected, slightly overweight volunteers, whose weight had been essentially stable for at least 2 weeks, The volunteers were divided into two groups, homogeneous for age, gender, and body weight. The test product (1.2 g) containing Phaseolus vulgaris (200 mg) and Garcinia cambogia (50 mg) and the placebo (1.2 g) were taken 6 tablets per day for 56 consecutive days, respectively. Each subject's body weight, body mass index (BMI), body fat, body fat ratio, and waist hip ratio (WHR) were measured. After 56 days (8 weeks), subjects receiving Block and burn ® had significantly greater reduction of body weight. Moreover, a significant changes of the BMI, body fat, and body fat ratio were observed in the test group compared to placebo. However, WHR was not statistically different between groups. These results indicated that Block and burn® produced significant decrements in body weight and suggested decrements in fat mass in the face of maintained lean body mass.

참고자료

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