특집/사이버나이프 로봇형 방사선수술장치를 이용한 암 치료 (Cyberknife Robotic Radiosurgery System for Cancer Treatment)

서지정보

· 발행기관 : 대한의사협회
· 수록지 정보 : 대한의사협회지 / 51권 / 7호 / 630 ~ 637페이지
· 저자명 : 김연실

초록

The Cyberknife is an integrated image-guided, frameless radiosurgery system. The physical
component includes a compact 6 MV X-band linear accelerator mounted to the mobile arm
of a robotic manipulator and a real- time imaging system connected to a remote image registration
console. Two orthogonally positioned diagnostic x-ray cameras provide real time images of
the patient’s internal anatomy during treatment. The images are processed automatically to
identify radiographic features, such as skull bone landmarks or implanted fiducials and are then
automatically compared with digitally reconstructed image of the patient’s planning CT. In this
processing, the direction of the radiation beam is continuously re-adjusted to reflect any changes
in the patient position. An analysis of the accuracy of the Cyberknife radiosurgery system found
that the machine has a clinically relevant accuracy of 1.0 ± 0.3mm. While clinical results with
intracranial lesions are comparable to frame-based radiosurgical technique using gamma-knife
or linac, recent experiences demonstrate the potential to broadly expand the scope of radiosurgery
to many extracranial sites especially for cancer patients. The major potential benefit of
radiosurgical ablation of malignant tumors are relatively short treatment time in an out-patients
setting combined with better local control of the tumor with minimal risk of side effects. Cyberknife
radiosurgery offers a new and alternative therapeutic modality for the medically inoperable early
cancers, previous irradiated sites, and difficult lesions not amenable to open surgery, as a boost
therapy with surgery or external radiation therapy or for rapid symptom relief of palliative care
patients. While we are encouraged by excellent local control of early clinical experiences of
Cyberknife, we also stressed the importance of long term follow-up results.

영어초록

The Cyberknife is an integrated image-guided, frameless radiosurgery system. The physical
component includes a compact 6 MV X-band linear accelerator mounted to the mobile arm
of a robotic manipulator and a real- time imaging system connected to a remote image registration
console. Two orthogonally positioned diagnostic x-ray cameras provide real time images of
the patient’s internal anatomy during treatment. The images are processed automatically to
identify radiographic features, such as skull bone landmarks or implanted fiducials and are then
automatically compared with digitally reconstructed image of the patient’s planning CT. In this
processing, the direction of the radiation beam is continuously re-adjusted to reflect any changes
in the patient position. An analysis of the accuracy of the Cyberknife radiosurgery system found
that the machine has a clinically relevant accuracy of 1.0 ± 0.3mm. While clinical results with
intracranial lesions are comparable to frame-based radiosurgical technique using gamma-knife
or linac, recent experiences demonstrate the potential to broadly expand the scope of radiosurgery
to many extracranial sites especially for cancer patients. The major potential benefit of
radiosurgical ablation of malignant tumors are relatively short treatment time in an out-patients
setting combined with better local control of the tumor with minimal risk of side effects. Cyberknife
radiosurgery offers a new and alternative therapeutic modality for the medically inoperable early
cancers, previous irradiated sites, and difficult lesions not amenable to open surgery, as a boost
therapy with surgery or external radiation therapy or for rapid symptom relief of palliative care
patients. While we are encouraged by excellent local control of early clinical experiences of
Cyberknife, we also stressed the importance of long term follow-up results.

참고자료

· 없음