배추출물과 구기자, 의이인, 택사, 황기 추출물 배합이 고지방식이로 유발된 비만 백서의 체중, 지질대사, 염증 및 면역기능에 미치는 영향 (Ⅱ) (Effect of pear extracts containing herbal medicine(Lycii Fructus, Coicis Semen, Alimatis Rhizoma and Astragali Radix) on body weight, lipid metabolism and immune responses in rats fed high fat diets ()

서지정보

· 발행기관 : 대한본초학회
· 수록지 정보 : 대한본초학회지 / 27권 / 5호 / 1 ~ 7페이지
· 저자명 : 김왕인, 나창수, 윤대환, 김황곤

초록

Objectives : This study was conducted to 9% compared with the previous experimental obesity-induced metabolic function in rats that it was a mixture of pear extract and herbal drugs(Lycii Fructus, Coicis Semen, Alimatis Rhizoma and Astragali Radix) on high fat diet-induce obesity rats. Methods : The animals were used in male rats. Control group fed high-fat diet only. Experimental groups were divided four, ExpⅠ group was fed high-fat diet with a mixture pear extract and Lycii Fructus 9%, Exp Ⅱ group was fed high-fat diet with a mixture pear extract and Coicis Semen 9%, Exp Ⅲ group was fed high-fat diet with a mixture pear extract and Alimatis Rhizoma 9%, and Exp Ⅳ group was fed high-fat diet with a mixture pear extract and Astragali Radix 9% for 4 weeks. Results : The body weight gain increased in all groups, but attenuated gradually in the experimental groups compared to the control group. The food intakes were significantly lower in all Exp groups than the control group. The concentrations of serum total cholesterol (TC), LDL-cholesterol, and free fatty acid were significantly lower in Exp Ⅱ than in the control group. Also the concentration of serum free fatty acid was significantly lower in the Exp Ⅳ group than in the control group. In inflammatory activities, the Exp Ⅱ, Ⅳ group was significantly lower than the control group. Conclusion : The results indicated that Exp Ⅰ group (administered a mixture of pear extract and Lycii Fructus) reduced fat accumulation, body weight and the highest elevated lipid metabolism, while the Exp Ⅱ group (administered the mixture of pear extract and Coicis Semen) and Exp Ⅳ group (administered the mixture of pear extract and Astragali Radix) had the highest elevated immune activity.

영어초록

Objectives : This study was conducted to 9% compared with the previous experimental obesity-induced metabolic function in rats that it was a mixture of pear extract and herbal drugs(Lycii Fructus, Coicis Semen, Alimatis Rhizoma and Astragali Radix) on high fat diet-induce obesity rats. Methods : The animals were used in male rats. Control group fed high-fat diet only. Experimental groups were divided four, ExpⅠ group was fed high-fat diet with a mixture pear extract and Lycii Fructus 9%, Exp Ⅱ group was fed high-fat diet with a mixture pear extract and Coicis Semen 9%, Exp Ⅲ group was fed high-fat diet with a mixture pear extract and Alimatis Rhizoma 9%, and Exp Ⅳ group was fed high-fat diet with a mixture pear extract and Astragali Radix 9% for 4 weeks. Results : The body weight gain increased in all groups, but attenuated gradually in the experimental groups compared to the control group. The food intakes were significantly lower in all Exp groups than the control group. The concentrations of serum total cholesterol (TC), LDL-cholesterol, and free fatty acid were significantly lower in Exp Ⅱ than in the control group. Also the concentration of serum free fatty acid was significantly lower in the Exp Ⅳ group than in the control group. In inflammatory activities, the Exp Ⅱ, Ⅳ group was significantly lower than the control group. Conclusion : The results indicated that Exp Ⅰ group (administered a mixture of pear extract and Lycii Fructus) reduced fat accumulation, body weight and the highest elevated lipid metabolism, while the Exp Ⅱ group (administered the mixture of pear extract and Coicis Semen) and Exp Ⅳ group (administered the mixture of pear extract and Astragali Radix) had the highest elevated immune activity.

참고자료

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