트레드밀 운동이 노화 흰쥐 대뇌조직의 MAO-B 활성, Acetylcholine, 지질과산화물 함량 및 기억력에 미치는 영향 (Effects of Treadmill Exercise on MOA-B Enzyme Activities, Acetylcholine, Lipid Peroxide Content and Memory Abilty in Aging Rat's Cerebrum)

서지정보

· 발행기관 : 한국생활환경학회
· 수록지 정보 : 한국생활환경학회지 / 18권 / 5호 / 570 ~ 579페이지
· 저자명 : 최대원, 김유미, 윤진환

초록

The aim of the present study was to investigate the effects of treadmill exercise on MOA-B enzyme activities,Acetylcholine, Lipid peroxide content and memory ability in aging rat's cerebrum. male F344 male rats (weighing 565-585 g) were used in this study. The rats were divided into three groups (n = 8 in each group): the sedentary groups (Con; n = 8), low intensity exercise groups (LIEG; n = 8), and high intensity exercise groups (HIEG; n = 8). The rats in the LIEG was force to run on a motorized treadmill at a speed of 5-8 m/min, 30 min/day, 4 days a week, for 12weeks. HIEG was forced to ran on motorized treadmill at a speed of 22-25 m/min, 30 min/day, 4 days a weeks, for 12 weeks. After 12 weeks of treadmill exercise, rats were tested on a step-throught passive avoidance task in order to evaluate the memory ability and than MOA-B enzyme activities, acetylcholine, lipid peroxide content in aging rat's cerebrum were measured. After 12 weeks treadmill exercise, The MOA-B activities and MDA levels of cerebrum were significantly (p < 0.05) lower in LIEG when compared to HIEG. The acetylcholin levels of cerebrum was significantly (p < 0.05) higher in both LIEG and HIEG when compared to CON. Memory ability was significantly (p < 0.05)increased in both LIEG and HIEG when compared to CON. Based on the present results, it is suggested that long-term treadmill exercise do not cause oxidant stress in aging rat's cerebrum. These results indicate that long-term low intensity exercise play a beneficial antioxidant role and memory in reducing the lipid peroxidant enhanced by improvement of MOA-B and acetylcholin activities in the aging rat's cerebrum.

영어초록

The aim of the present study was to investigate the effects of treadmill exercise on MOA-B enzyme activities,Acetylcholine, Lipid peroxide content and memory ability in aging rat's cerebrum. male F344 male rats (weighing 565-585 g) were used in this study. The rats were divided into three groups (n = 8 in each group): the sedentary groups (Con; n = 8), low intensity exercise groups (LIEG; n = 8), and high intensity exercise groups (HIEG; n = 8). The rats in the LIEG was force to run on a motorized treadmill at a speed of 5-8 m/min, 30 min/day, 4 days a week, for 12weeks. HIEG was forced to ran on motorized treadmill at a speed of 22-25 m/min, 30 min/day, 4 days a weeks, for 12 weeks. After 12 weeks of treadmill exercise, rats were tested on a step-throught passive avoidance task in order to evaluate the memory ability and than MOA-B enzyme activities, acetylcholine, lipid peroxide content in aging rat's cerebrum were measured. After 12 weeks treadmill exercise, The MOA-B activities and MDA levels of cerebrum were significantly (p < 0.05) lower in LIEG when compared to HIEG. The acetylcholin levels of cerebrum was significantly (p < 0.05) higher in both LIEG and HIEG when compared to CON. Memory ability was significantly (p < 0.05)increased in both LIEG and HIEG when compared to CON. Based on the present results, it is suggested that long-term treadmill exercise do not cause oxidant stress in aging rat's cerebrum. These results indicate that long-term low intensity exercise play a beneficial antioxidant role and memory in reducing the lipid peroxidant enhanced by improvement of MOA-B and acetylcholin activities in the aging rat's cerebrum.

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