무후각증 환자에서 흡수성 비강 충전물을 이용한 직접적인 Triamcinolone 적용의단기 효능과 안정성 (Short-Term Efficacy and Safety of the Direct Triamcinolone Application Using Absorbable Nasal Packing in Anosmic Patients)

서지정보

· 발행기관 : 대한이비인후과학회
· 수록지 정보 : 대한이비인후-두경부외과학회지 / 66권 / 10호 / 670 ~ 677페이지
· 저자명 : 정종인, 박재석, 김효열

초록

Background and Objectives The most common treatment for olfactory dysfunction is theuse of glucocorticoids. However, using systemic glucocorticoids is limited due to systemicside effects, and topical glucocorticoids are less effective than systemic glucocorticoids. Theaim of this study is to evaluate short-term therapeutic effects of direct triamcinolone (TA) ap-plication using absorbable nasal packing material on anosmia patients.
Subjects and Method This was a retrospective study that evaluated patients who were di-agnosed with anosmia and treated with oral prednisolone (PD) pulse therapy or 2 times of a 20mg dose of TA impregnated absorbable nasal packing in both olfactory clefts. Information of thedemographic features, the self-reporting olfaction scores (visual analogue scale [VAS], 0-10),and the threshold, discrimination, identification (TDI) scores of Korean version of the Sniffin’stick test II were collected and analyzed.
Results The data of 72 patients were analyzed in this study: 30 patients were treated withTA nasal packing, and 42 patients with oral PD. In both group, VAS and TDI scores were sig-nificantly improved 2 weeks after treatment. The rate of significant olfactory improvement ofTA nasal packing group was higher than oral PD group (60.0% vs. 47.6%), but there was nostatistically significant difference ( p=0.300). There was no significant systemic adverse effectafter TA nasal packing treatments.
Conclusion Direct TA application using absorbable nasal packing is a possible treatment op-tion in anosmic patients.

영어초록

Background and Objectives The most common treatment for olfactory dysfunction is theuse of glucocorticoids. However, using systemic glucocorticoids is limited due to systemicside effects, and topical glucocorticoids are less effective than systemic glucocorticoids. Theaim of this study is to evaluate short-term therapeutic effects of direct triamcinolone (TA) ap-plication using absorbable nasal packing material on anosmia patients.
Subjects and Method This was a retrospective study that evaluated patients who were di-agnosed with anosmia and treated with oral prednisolone (PD) pulse therapy or 2 times of a 20mg dose of TA impregnated absorbable nasal packing in both olfactory clefts. Information of thedemographic features, the self-reporting olfaction scores (visual analogue scale [VAS], 0-10),and the threshold, discrimination, identification (TDI) scores of Korean version of the Sniffin’stick test II were collected and analyzed.
Results The data of 72 patients were analyzed in this study: 30 patients were treated withTA nasal packing, and 42 patients with oral PD. In both group, VAS and TDI scores were sig-nificantly improved 2 weeks after treatment. The rate of significant olfactory improvement ofTA nasal packing group was higher than oral PD group (60.0% vs. 47.6%), but there was nostatistically significant difference ( p=0.300). There was no significant systemic adverse effectafter TA nasal packing treatments.
Conclusion Direct TA application using absorbable nasal packing is a possible treatment op-tion in anosmic patients.

참고자료

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