알츠하이머병 환자에서 맥락망총과 망상아형과의 연관성 (Choroid Plexus and Its Association of Subtypes of Delusion in Patient With Alzheimer’s Disease)

서지정보

· 발행기관 : 대한노인정신의학회
· 수록지 정보 : 노인정신의학 / 26권 / 1호 / 18 ~ 22페이지
· 저자명 : 손성미, 이영민, 박제민, 이병대, 문은수, 정희정, 서화규, 김경원, 김학진, 박경준, 최경운

초록

Objective: This study examined the volume of choroid plexus across AD without delusion (AD-D), AD with paranoid delusion (AD+PD), and AD with misidentification delusion (AD+MD).
Methods: This is a hospital based cross-sectional study of patients with AD. The main outcome measure is the volume of choroid plexus that were measured as regions of interest with magnetic resonance imaging and the FreeSurfer analysis at baseline. Analysis of covariance (ANCOVA) was conducted to compare the differences on the volume of choroid plexus across AD-D, AD+PD, and AD+MD after controlling demographics.
Results: There was no volume difference in the both choroid plexus between AD-D and AD+D. However, the volumes of both choroid plexus were significantly reduced in AD+MD compared to AD+PD.
Conclusion: Our study demonstrates that AD+MD has significantly reduced volumes of choroid plexus compared to AD+PD.
These findings suggest that AD+MD and AD+PD may have different pathophysiological mechanisms related to neuroimmune responses in the choroid plexus

영어초록

Objective: This study examined the volume of choroid plexus across AD without delusion (AD-D), AD with paranoid delusion (AD+PD), and AD with misidentification delusion (AD+MD).
Methods: This is a hospital based cross-sectional study of patients with AD. The main outcome measure is the volume of choroid plexus that were measured as regions of interest with magnetic resonance imaging and the FreeSurfer analysis at baseline. Analysis of covariance (ANCOVA) was conducted to compare the differences on the volume of choroid plexus across AD-D, AD+PD, and AD+MD after controlling demographics.
Results: There was no volume difference in the both choroid plexus between AD-D and AD+D. However, the volumes of both choroid plexus were significantly reduced in AD+MD compared to AD+PD.
Conclusion: Our study demonstrates that AD+MD has significantly reduced volumes of choroid plexus compared to AD+PD.
These findings suggest that AD+MD and AD+PD may have different pathophysiological mechanisms related to neuroimmune responses in the choroid plexus

참고자료

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