Streptococcus mutans 에 대한 티타늄 합금 산화막의 광촉매 항균효과 (Photocatalytic antibacterial effect of TiO2 film of titanium alloys on Streptococcus mutans)

서지정보

· 발행기관 : 대한치과재료학회
· 수록지 정보 : 대한치과재료학회지 / 35권 / 4호 / 329 ~ 338페이지
· 저자명 : 문승균, 탁창우, 주욱현, 오근택, 이용근, 김광만, 김경남

초록

Titanium and it's alloys are widely used in medical fields because of their light weight, high biocorrosion resistance, biocompatibility and good mechanical properties, which include a low elastic modulus. There is a few research about the TiO₂ photocatalytic effect of titanium alloy.
This study compared the antibacterial activity and evaluated the photocatalytic effect on Streptococcus mutans from titanium alloys(S. mutans IFO 13955). The experimental groups were TiAg, TiAu, TiCu, TiPd and TiPt alloys, respectively and control group was cp-Ti. Arc melting, homogenization, hot rolling, solution heat treatment and anode-oxidation were performed to prepare titanium alloys. And the specimens were anodic-oxidized at 250 V for 3 minutes. First, the surface characterization was analyzed by x-ray diffraction, scanning electron microscope and video contact angle measuring system. Second, the antibacterial effect of the alloys was studied by bacterial activity test.
From the result of XRD analysis, TiO₂-anatase phase and Ti-α phase were formed on the surface of every titanium alloys. The structure of titanium oxide would be changed into anatase phase by anodic oxidation process. In the SEM observation, the result showed an anode-oxidation treatment, indicating that the each film had a micro-pore structure. Many particles were also observed on TiAu and TiCu surfaces. From the contact angle measurement, experimental groups were not different from the control group. In the bacterial activity test, the survival rate of S. mutans dropped on various specimens as a function of time. In illumination for 20 min, the antibacterial effect of TiAu and TiCu was better than other titanium alloys. After the illumination for 60 min, the survival rate constant of titanium alloys was not different from cp-Ti with increasing illuminating time.
From the above results, we can conclude that TiO₂ of TiAu, TiCu could be expected for the useful antibacterial biomaterial under the UV illumination. Further study on the biocompatibility and surface characterization analysis are necessary to ensure that these materials can be safely used in the dental and medical fields.

영어초록

Titanium and it's alloys are widely used in medical fields because of their light weight, high biocorrosion resistance, biocompatibility and good mechanical properties, which include a low elastic modulus. There is a few research about the TiO₂ photocatalytic effect of titanium alloy.
This study compared the antibacterial activity and evaluated the photocatalytic effect on Streptococcus mutans from titanium alloys(S. mutans IFO 13955). The experimental groups were TiAg, TiAu, TiCu, TiPd and TiPt alloys, respectively and control group was cp-Ti. Arc melting, homogenization, hot rolling, solution heat treatment and anode-oxidation were performed to prepare titanium alloys. And the specimens were anodic-oxidized at 250 V for 3 minutes. First, the surface characterization was analyzed by x-ray diffraction, scanning electron microscope and video contact angle measuring system. Second, the antibacterial effect of the alloys was studied by bacterial activity test.
From the result of XRD analysis, TiO₂-anatase phase and Ti-α phase were formed on the surface of every titanium alloys. The structure of titanium oxide would be changed into anatase phase by anodic oxidation process. In the SEM observation, the result showed an anode-oxidation treatment, indicating that the each film had a micro-pore structure. Many particles were also observed on TiAu and TiCu surfaces. From the contact angle measurement, experimental groups were not different from the control group. In the bacterial activity test, the survival rate of S. mutans dropped on various specimens as a function of time. In illumination for 20 min, the antibacterial effect of TiAu and TiCu was better than other titanium alloys. After the illumination for 60 min, the survival rate constant of titanium alloys was not different from cp-Ti with increasing illuminating time.
From the above results, we can conclude that TiO₂ of TiAu, TiCu could be expected for the useful antibacterial biomaterial under the UV illumination. Further study on the biocompatibility and surface characterization analysis are necessary to ensure that these materials can be safely used in the dental and medical fields.

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